ID A0A2Y9LTM8_DELLE Unreviewed; 758 AA.
AC A0A2Y9LTM8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Actin-binding LIM protein 2 isoform X15 {ECO:0000313|RefSeq:XP_022410442.1};
GN Name=ABLIM2 {ECO:0000313|RefSeq:XP_022410442.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022410442.1};
RN [1] {ECO:0000313|RefSeq:XP_022410442.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022410442.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_022410442.1; XM_022554734.2.
DR AlphaFoldDB; A0A2Y9LTM8; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd09327; LIM1_abLIM; 1.
DR CDD; cd09328; LIM2_abLIM; 1.
DR CDD; cd09329; LIM3_abLIM; 1.
DR CDD; cd09330; LIM4_abLIM; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR032402; AbLIM_anchor.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24213; ACTIN-BINDING LIM PROTEIN; 1.
DR PANTHER; PTHR24213:SF6; ACTIN-BINDING LIM PROTEIN 2; 1.
DR Pfam; PF16182; AbLIM_anchor; 1.
DR Pfam; PF00412; LIM; 4.
DR Pfam; PF02209; VHP; 1.
DR SMART; SM00132; LIM; 4.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 6.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 175..234
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 235..294
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 304..363
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 690..758
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..641
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 84091 MW; D455D4E05AA006BE CRC64;
MPAATRIWTG REGSSRRAQR EPCPADTWIS AQWYRLWTSG FQNCCLTSLC WFVTTATRNE
YTSEQTTPKR RGRTRQSVFL AGGLRAGRGS ANQARLRGGG SAPSPTLLLG PAGGRSTVGQ
REPPSAWTQN WNIVTSTRVP WPSQPHEPAQ RGDPGEVSEP QAARSAPEKP ASTAILCNTC
GNVCRGEVLR VQSKYFHIQC FVCKECGCDL AEGGFFVRQG EYICTQDYQR LYGTRCFSCD
QFIEGEVVSA LGKTYHPNCF VCAVCRLPFP PGDRVTFNGK ECMCQKCSLP TSAGSSVPLS
QGLWSCKGCG VEIKNGQSLV ALEKHWHLGC FKCKTCGKQL NAEYISKDGL PYCEADYHSK
FGIRCDGCEK YITGHVLEAG EKHFHPLCAL CVGCGRMFAE GEEMYLQGSS IWHPACRQAA
RTEDKSKETR TSSESIISVP ASSTSGSPSR VIYAKLGDEI LDYRDLAALP KNKAIYSIDR
PDMISYSPFI SHSVGDRQSC SEGYQDDRSY KQCRTSSPSS TGSVSLGRYT PTLRSPQHYS
RPAGTLSVGT SSCLSLSQHP SPTSVFRHHY IPYFRGSESG RSTSSLSVLS DSKPPPSTYQ
QAPRHFHVPD TGVKDNIYRK PPIYKQHAGR RSDGEDGSFD ADNRKKTNWL LLKGDGDTRT
NSPDLDSQSL AHSSGTDRGP LQTMPGDNIY SQYKIYPYDA LIVTNRIRVK LPKDVDRTRL
ERHLSPEEFQ EVFGMSMEEF DRLALWKRND LKKKALLF
//
