ID   A0A2Y9LUX4_DELLE        Unreviewed;       850 AA.
AC   A0A2Y9LUX4;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Transforming growth factor beta receptor type 3 isoform X2 {ECO:0000313|RefSeq:XP_022409098.1};
GN   Name=TGFBR3 {ECO:0000313|RefSeq:XP_022409098.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409098.1};
RN   [1] {ECO:0000313|RefSeq:XP_022409098.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022409098.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022409098.1; XM_022553390.1.
DR   AlphaFoldDB; A0A2Y9LUX4; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR   Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR   InterPro; IPR042235; ZP-C.
DR   InterPro; IPR048290; ZP_chr.
DR   InterPro; IPR001507; ZP_dom.
DR   InterPro; IPR017977; ZP_dom_CS.
DR   PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR   PANTHER; PTHR14002:SF7; TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3; 1.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   PRINTS; PR00023; ZPELLUCIDA.
DR   SMART; SM00241; ZP; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS00682; ZP_1; 1.
DR   PROSITE; PS51034; ZP_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_022409098.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..850
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015884397"
FT   TRANSMEM        784..808
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          454..729
FT                   /note="ZP"
FT                   /evidence="ECO:0000259|PROSITE:PS51034"
FT   REGION          388..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          816..850
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   850 AA;  93678 MW;  68166BC6D0BC8295 CRC64;
     MASRCVIAMF ALMSSCLATA GPEPSAQCEL LPVNASHPVQ ALMESFTVLS GCASRGTVGL
     PQEVHVLNLR TADQGPGQPQ REVTLHLNPI SSVYIHHKPV VFLLNSPQPL VWHLKTERLA
     IGISRLFLVS EGSVVHFSSG NFSLSAETEE RSFPHGNEHL LNWARKEYGA VTSFTELKIA
     RNIYIKVGED QVFPPTCNIG KNFLSLNYLA GYLQPKAAEG CVISSQPRDK EVHIIELITP
     NSNPYSAFQV DIIIDIRPSR KDPEVVKDLI LILKCKKSVN WVIKSFDIKG NLKVIAPNSI
     GFGKESERSM IMTKSIRDDI PSTQESLVKW ALDNGCSPVT SYTVAPVANR FHLRLENNEE
     MRDEEVHTIP PELRILLDPG NLPALDNPRI RGRGGQNGGF PFPFPDISRR GWKEGGEDGI
     PRPKDPVIPS IQLFPGPREA EEVQGSMDVA LSVKCDNEKM TVAIEKDSFQ ARGYSGMELT
     LLDPTCKAKM NGTHFILESP LNGCGTRHRR SVPYGVVYYN SIVIQVPPPG DSSGWPDGYE
     DLESGDNGFP GDTDEGDTSF FSRPEIVVFN CSLRQVGNPS SFQDPPNRNV TFNMELYNTD
     LFLVPSQGVF SVAENGHVFV EVSVTKADQE LGFAIQTCFI SPYSNPDRMS DYTIIENICP
     KDESVKFYNP KRVHFPIPQA EIDKKRFSFV FKPIFNTSLL FLQCELTLCT KKEKDPQKLP
     KCVLPDEACT SLDASMIWAM MQNKKTFTKP LAVIHHEVQL KETGPSIKKP IPVSPPIFHG
     LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETAGRQQV PTSPPASENS SAAHSIGSTQ
     STPCSSSSTA
//