ID A0A2Y9LVA1_DELLE Unreviewed; 1108 AA.
AC A0A2Y9LVA1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA helicase MCM9 {ECO:0000256|ARBA:ARBA00041085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 9 {ECO:0000256|ARBA:ARBA00042301};
GN Name=MCM9 {ECO:0000313|RefSeq:XP_022410962.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022410962.1};
RN [1] {ECO:0000313|RefSeq:XP_022410962.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022410962.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR RefSeq; XP_022410962.1; XM_022555254.2.
DR AlphaFoldDB; A0A2Y9LVA1; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR CDD; cd17760; MCM9; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000313|RefSeq:XP_022410962.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_022410962.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 302..505
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 623..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..845
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 122931 MW; 20C4AAE2551C9D91 CRC64;
MNSDQVTLVG QVFESYVSEY HKNDILLILK ERDEDAHYPV VVNAMTLFET NMEIGEYFNV
FPNEVLTIFD SALQRSALTI LQSLSQLEGV SMKQNLHARI SGLPVCPELV REHIPRTKDV
GHFLSVTGTV IRTSLVKILE FERDYMCNKC KHVFVVRADF EQYYTFCRPS SCPSLESCDS
AKFTCLSDLS SSPTRCRDYQ EIKIQEQVQR LSVGSIPRTM KVILEDDLVD SCKSGDDLTI
YGVVMQRWKP FQQDVRCEVE IVLKANYVQV NNEQSAGINM DEEVRKEFED FWEYYKSDPF
AGRNEILASL CPQVFGMYLV KLAVALVLAG GIQRTDATGT RVRGESHLLL VGDPGTGKSQ
FLKYAAKITP RSVLTTGIGS TSAGLTVTAV KDSGEWNLEA GALVLADAGL CCIDEFNSLK
EHDRTSIHEA MEQQTISVAK AGLVCKLNTR TTILAATNPK GQYDPHESVS VNIALGSPLL
SRFDLILVLL DTKNEDWDRI ISAFILENKG YPSKSEKLWS MEKMKTYFCL IRNLQPTLSD
EAHARLMFRD TVTLEDAITV VSVMESSMQG GALLGGVNAL HTSFPDNPLE QYQKQCELIL
EKLELHSLLR EELRRLERLQ NQSVCQHQPR AMEAETTSGS LRDDPGEESK FRPSAQQEVN
CSTRLSSTGG RPGGSPLLNP PSHLGPDRLT SRRHSAEHKN SQDDSLDWFD SIATHPMEPK
NTVPVSPSPK TSGGEMALKI SNNKSQGKEK REPGQRSKLE TGPLPTPEET EAPLRPDSLE
GEKAKKAAMV SEAGVSADEP DSVLTHHVPR KLHKLRKERA QEWCRNPARP PSQPTSSPHP
RPTPVQSPER VLGTPKRKRQ KSLARVQEPH LESVESPGPP VAKLAKFTFK KKSKLIHSPE
DCSPVSPGTS ETAVQSPEIP QRRARGKAAL PGKGPDKLAS TSEVRSPAQL QDKTKEVSRQ
PPDRDGPREK RERALAKGAV QPELELGSNT GRFHLASERD REEEVSCHSK SGKVHACTLV
RLANFSFTSP SESKSESPPP PESKNPGEGG PSPLLVTAAT VLGRKRKTFQ LGGSTERLSL
SKTSLFTLPE LDDEPLDFDW DEEIRKKP
//
