ID A0A2Y9LVI8_DELLE Unreviewed; 535 AA.
AC A0A2Y9LVI8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=T-box transcription factor TBX21 {ECO:0000313|RefSeq:XP_022413714.1};
GN Name=TBX21 {ECO:0000313|RefSeq:XP_022413714.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022413714.1};
RN [1] {ECO:0000313|RefSeq:XP_022413714.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022413714.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_022413714.1; XM_022558006.1.
DR AlphaFoldDB; A0A2Y9LVI8; -.
DR STRING; 9749.A0A2Y9LVI8; -.
DR Ensembl; ENSDLET00000006302; ENSDLEP00000005690; ENSDLEG00000004247.
DR KEGG; dle:111166371; -.
DR InParanoid; A0A2Y9LVI8; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0071310; P:cellular response to organic substance; IEA:Ensembl.
DR GO; GO:0072676; P:lymphocyte migration; IEA:Ensembl.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
DR GO; GO:2000329; P:negative regulation of T-helper 17 cell lineage commitment; IEA:Ensembl.
DR GO; GO:2000552; P:negative regulation of T-helper 2 cell cytokine production; IEA:Ensembl.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR GO; GO:2000556; P:positive regulation of T-helper 1 cell cytokine production; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR GO; GO:0002296; P:T-helper 1 cell lineage commitment; IEA:Ensembl.
DR CDD; cd20203; T-box_TBX21; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF125; T-BOX TRANSCRIPTION FACTOR TBX21; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 141..326
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 58351 MW; 12F4A0AE974D4C8A CRC64;
MGILEPSCRD MLTGTDPMPA SDEGRAPGAD SQNRYFYPEP GAQDAADRRV GASLGAPYAG
GALVPAPPGR FLGAYAYPPR HQATGFPGAG EPFPPTPGAE GYQPGDAYTA PDPRATLYPG
PREDCALPAG LEVSGKLRVA LNNHLLWSKF NQHQTEMIIT KQGRRMFPFL SFTVAGLEPT
SHYRIFVDMV LVDQHHWRYQ SGKWVPCGKA GGNMPGNRLY VHPDSPNTGA HWMRQEVSFG
KLKLTNNKGA SNNVTQMIVL QSLHKYQPRL HIVEVSDGEP EAACNASNTH IFTFQETQFI
AVTAYQNAEI TQLKIDNNPF AKGFRENFES MYASVDTSVL SPPGPNCQLL GGDHYSRLLP
SQCPVPSCFY PNLPSQAKDV VPQPYWLGAP RDHSYEAEFR AVSMKPSFLP SASGSTMSYY
RSQEVLAPGA GWPVTPQYPP KMGPTSWFRS TRTLPMEPGP GASEGRGPED QGSPSLWTEI
TPIRPESSDS GLGEGDSKRR RVSPYPSSGD SSSPAGAPSP FDKETEGQFY NYFPN
//
