ID A0A2Y9LVJ7_DELLE Unreviewed; 712 AA.
AC A0A2Y9LVJ7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Low-density lipoprotein receptor-related protein 10 {ECO:0000313|RefSeq:XP_022409303.1};
GN Name=LRP10 {ECO:0000313|RefSeq:XP_022409303.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409303.1};
RN [1] {ECO:0000313|RefSeq:XP_022409303.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022409303.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR RefSeq; XP_022409303.1; XM_022553595.2.
DR AlphaFoldDB; A0A2Y9LVJ7; -.
DR STRING; 9749.A0A2Y9LVJ7; -.
DR Ensembl; ENSDLET00000030579; ENSDLEP00000027825; ENSDLEG00000020034.
DR KEGG; dle:111164183; -.
DR InParanoid; A0A2Y9LVJ7; -.
DR OrthoDB; 2916406at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF17; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 10; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 4.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Lipoprotein {ECO:0000313|RefSeq:XP_022409303.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_022409303.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..712
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015857506"
FT TRANSMEM 440..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..304
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 533..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..561
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..644
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 139..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 146..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 158..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 337..352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 380..395
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 398..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 405..423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 417..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 712 AA; 76344 MW; 784E0DF753B29923 CRC64;
MLPAILLLLL GDAVAHPDRI IFPNPACEDP PAVLLEVQGT LQRPVGRDSR SSPANCTWLI
LGSKEQTVTV RFQKLRLACG SERLILRSPI QPQISLCEAP ASPLQLPGGN VTITYSYAGA
RAPMGQGFLL SYSQDWLMCL QEEFQCLNHR CVPLVQRCDG VDACGDGSDE AGCSSDPFPN
LTPGPVPTPP CNHTLEDFYG VFSSLGYSHL ASVSHPQSCL WLLDPHDGRR LAVRFTALDL
SYGDAVHVYD GAGPPETLRL LRSLTHFSNG KAVTVETLSG QATVDYHTVA WSSGRGFNAT
YHVRGYCLPW DRPCGLGSGL GASEGLGERC YSEAQRCDGS WDCADGTDEE NCPSCPPGHY
PCGAAGTPGA TACYLPADRC NYQTFCADGA DERRCRHCQP GNFRCRDEKC VYETWVCDGQ
PDCADGSDEW DCPYALPRKV ITAAVIGSLV CGLLLVIALG CTCKLYAIRT QEYSIFAPLS
RTEAEIVQQQ APPSYGQLIA QGAIPPVEDF PTENPNDNSV LGNLRSLLQI LRQDMTPGGA
SGTRRRQRGR SMRRLVRRLR RWGLLPRTSP PARTSETRSQ VTPSAAPPET LDGSTGPARE
GGAVGGQDGE QAPPLPVKAP LPPASTSPAF PTVPEAPGPL PAAPLEPSLL SGVVQALRGR
LLPSLRPPGP TRAPPGPHTT VLSPEDEDDV LLVPLAEPGV WVVEAEDEPL LV
//
