ID A0A2Y9LXG2_DELLE Unreviewed; 275 AA.
AC A0A2Y9LXG2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=R-spondin-3 {ECO:0000313|RefSeq:XP_022411737.1};
GN Name=RSPO3 {ECO:0000313|RefSeq:XP_022411737.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022411737.1};
RN [1] {ECO:0000313|RefSeq:XP_022411737.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022411737.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the R-spondin family.
CC {ECO:0000256|ARBA:ARBA00007308}.
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DR RefSeq; XP_022411737.1; XM_022556029.2.
DR AlphaFoldDB; A0A2Y9LXG2; -.
DR STRING; 9749.A0A2Y9LXG2; -.
DR Ensembl; ENSDLET00000017167; ENSDLEP00000015541; ENSDLEG00000011448.
DR KEGG; dle:111165408; -.
DR InParanoid; A0A2Y9LXG2; -.
DR OrthoDB; 196918at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005109; F:frizzled binding; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
DR GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR043601; Rspo_Fu-CRD_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR PANTHER; PTHR46987; NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46987:SF1; R-SPONDIN-3; 1.
DR Pfam; PF15913; Furin-like_2; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR SMART; SM00261; FU; 2.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 3: Inferred from homology;
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..275
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015873464"
FT DOMAIN 43..142
FT /note="R-spondin Fu-CRD"
FT /evidence="ECO:0000259|Pfam:PF15913"
FT DOMAIN 148..203
FT /note="Spondin-like TSP1"
FT /evidence="ECO:0000259|Pfam:PF19028"
FT REGION 203..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 31248 MW; CDEC895A67E0AB72 CRC64;
MHLRLISCFF IILNFLEYIG SQNASRGRRQ RRMHPNVSQG CQGGCATCSD YNGCLSCKPK
LFFVLERIGM KQIGVCLSSC PSGYYGTRYP DINKCTKCKA DCDTCFNKNF CTKCKSGFYL
HLGKCLDNCP EGLEANNHTM ECVSIVHCEA SEWSPWSPCT KKGKTCGFKR GTETRVREII
QHPSAKGNLC PPTSETRKCT VQRKKCQKGE RGKKGRERKR KKLNKEESKD AIPDNKGLEP
SRETPEQREN KDKQQQKKRK VQDKQQKSVS VSTVH
//
