UniProt: A0A2Y9LXW9

Database: UniProt
Entry: A0A2Y9LXW9_DELLE

LinkDB:  A0A2Y9LXW9_DELLE 
Original site:  A0A2Y9LXW9_DELLE

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Ontology (3)   
   GO (3)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (11)   
   InterPro (7)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (18)   

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ID   A0A2Y9LXW9_DELLE        Unreviewed;       570 AA.
AC   A0A2Y9LXW9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit beta-1 {ECO:0000256|ARBA:ARBA00019007};
DE   AltName: Full=Calcium channel voltage-dependent subunit beta 1 {ECO:0000256|ARBA:ARBA00030525};
GN   Name=CACNB1 {ECO:0000313|RefSeq:XP_022413641.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022413641.1};
RN   [1] {ECO:0000313|RefSeq:XP_022413641.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022413641.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC       {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004278}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC       {ECO:0000256|ARBA:ARBA00010836}.
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DR   RefSeq; XP_022413641.1; XM_022557933.2.
DR   AlphaFoldDB; A0A2Y9LXW9; -.
DR   Ensembl; ENSDLET00000021845; ENSDLEP00000019816; ENSDLEG00000014412.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR046937; CAB1-4_N_A-dom.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR005443; VDCC_L_b1su.
DR   InterPro; IPR000584; VDCC_L_bsu.
DR   PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR   PANTHER; PTHR11824:SF17; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR   PRINTS; PR01626; LCACHANNELB.
DR   PRINTS; PR01627; LCACHANNELB1.
DR   SMART; SM00072; GuKc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022568};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   DOMAIN          100..169
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          494..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   570 AA;  62639 MW;  4C7BD8ED4C56326B CRC64;
     MVQKTSMSRG PYPSSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA
     ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSLGDEVP
     VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQKLRQNR
     LSSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKLVTDM MQKALFDFLK HRFDGRISIT
     RVTADISLAK RSVLNNPSKH IIIERSNTRS SLAEVQSEIE RIFELARTLQ LVALDADTIN
     HPAQLSKTSL APIIVYIKIT SPKVLQRLIK SRGKSQSKHL NVQIAASEKL AQCPPEMFDI
     ILDENQLEDA CEHLAEYLEA YWKATHPPSS TPPNPLLNRT MATAALAASP APVSNLQGPY
     LASGDQSLER ATGEHASVHE YPGELGQPPG LYPGSQPPGR AGTLRALSHQ DTFDADTPGN
     RNSAYTELGD SCVDMETDPS EGPGLGDPAG GSTPPARQGS WEDEEDYEEE LTNNRNRGRN
     KARYCAEGGA PVLGRNKNEL QGWGRGVYIR
//

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