ID A0A2Y9LXX4_DELLE Unreviewed; 498 AA.
AC A0A2Y9LXX4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=BDNF/NT-3 growth factors receptor isoform X7 {ECO:0000313|RefSeq:XP_022414584.1};
GN Name=NTRK2 {ECO:0000313|RefSeq:XP_022414584.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022414584.1};
RN [1] {ECO:0000313|RefSeq:XP_022414584.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022414584.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022414584.1; XM_022558876.2.
DR AlphaFoldDB; A0A2Y9LXX4; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd05855; IgI_TrkB_d5; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR020777; NTRK.
DR InterPro; IPR020455; NTRK2.
DR InterPro; IPR031635; NTRK_LRRCT.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF33; MUSCLE ASSOCIATED RECEPTOR TYROSINE KINASE; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF16920; LRRCT_2; 1.
DR Pfam; PF01462; LRRNT; 1.
DR PRINTS; PR01939; NTKRECEPTOR.
DR PRINTS; PR01941; NTKRECEPTOR2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_022414584.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..498
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015937111"
FT TRANSMEM 431..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..282
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 498 AA; 55501 MW; 54D9CEF57E4F06DB CRC64;
MSSWTRWHGP AMAQLWGFCW LVVGFWRAAL ACPTSCKCSA SRIWCSDPFP GIVAFPRLES
TSADPENITE IYIANQKRLE IINEDDIEAY VGLKNLTIVD SGLKFVAHKA FLKNSNLQHI
NFTRNKLTVL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQETKPSPE TQDLYCLDEN
SKNISLANLQ ISHCGLPSAN LAAPNLTVEE GKSITLTCSV AGDPVPNLYW DVGNLVSKHM
NETSHTQGSL RITNVSSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYK
LVAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST
DVADKTGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKAQLCE IRHHYLYLLN
GDPETQGGCF TCLRPRST
//
