ID   A0A2Y9LXY8_DELLE        Unreviewed;       913 AA.
AC   A0A2Y9LXY8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL7 {ECO:0000313|RefSeq:XP_022413661.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022413661.1};
RN   [1] {ECO:0000313|RefSeq:XP_022413661.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022413661.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   RefSeq; XP_022413661.1; XM_022557953.1.
DR   AlphaFoldDB; A0A2Y9LXY8; -.
DR   KEGG; dle:111166347; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF85; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 7; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          47..157
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          363..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          847..874
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        9..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   913 AA;  101930 MW;  AEFB8EBE084358C1 CRC64;
     MDFQERDPPS LAESTQSAKP SSAQQASELW EVVEEPRGRL GAEGIMPERQ EGHLLKKRKW
     PLKGWHKRYF VLEDGILHYG TTRQDEQGTK GLDTQALSKK ITKGKLHGSI DVRLSVMSIN
     KKAQRIDLDT EDNIYHLKIK SQDLFQSWVA QLRAHRLAQH PDVPRSLLPS TTHRKVPGAQ
     LPAAGSASAL PGVGPREKVS SWLRDSDGLD RCSHELSECQ GKLQELHRLL QSLESLPRIP
     SAPVIPTHQA SVTTERPKKG KRTSRMWCTQ SFAKDDSIGR VGRLHGSVPN LSRYLESRDP
     SGPRGLPPPD YAHVQRSFWA LAQKVHSSLS SVLAALTTER DRLRDLHQGS EPSRLGVRLG
     AGWPVGGAGP SPEDCRPGGG PGPGPGREVG GGRLRPAGWG GLHPPRPGTC ALTLSLQVSE
     AAAGPRRLHS LSVSSDTTAD SFSSLNPEEQ EALYMKGREL TPQLSQSSVL SLADSHTEFF
     DACEVLLSAS SSENEGSEEE ESCTSEVTTS LSEEVLDLRG AERCQKGGAV GPPRRRCLPA
     ASGPGADVSL WNILWNNIGK DLSKVSMPVQ LNEPLSTLQR LCEELEYSSL LDQASQTTDP
     CERMVYIAAF AVSAYSSTYH RAGCKPFNPV LGETYECERP DRGFRFISEQ VSHHPPISAC
     HAESENFIFW QDMKWKNKFW GKSLEIVPVG MVNVSLPRFG DHFEWNKVTS CIHNILSGQR
     WIEHYGEVLI RNTQDSSCHC KITFCKAKYW SSNVHEVQGA VFSRSGRVLH RLFGKWPEGL
     YRGPPPGGQC IWKPNSMPPN YERNFGFTQF ALELNELTAE LKRSLPSTDT RLRPDQRYLE
     EGNIQAAEAQ KRRIEQLQRD RRKVMEENNI VHQARFFRRQ TDSSGKEWWV TNNTYWRLRA
     EPGYGNLDGA VLW
//