ID A0A2Y9LYN4_DELLE Unreviewed; 1267 AA.
AC A0A2Y9LYN4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1 isoform X2 {ECO:0000313|RefSeq:XP_022410308.1};
GN Name=RASGRF1 {ECO:0000313|RefSeq:XP_022410308.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022410308.1};
RN [1] {ECO:0000313|RefSeq:XP_022410308.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022410308.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022410308.1; XM_022554600.2.
DR AlphaFoldDB; A0A2Y9LYN4; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 240..426
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 467..584
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 631..746
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1022..1267
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 708..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 721..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1267 AA; 143257 MW; AFD75C1A8443AF39 CRC64;
MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL LFYFESDSSS
RPSGLYLLEG CVCDRAPSPK PTLSAKEPLE KQHYFTVNFS HENQKALELR TEDARDCDEW
VAAIAHASYR TLATEHEALM QKYLHLLQIV ETEKTVAKRL RQQIEDGEIE IERLKAEIAS
LLKDNERIQS TQTVTPNDED SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK
RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL
KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS
RIMHDEVSET ENIRKNLAIE RMIIEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG
SLSLKKEGER QCFLFSKHLI ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG
QDIDHLDFKI GVEPKDSPPF TVILVASSRQ EKVAWTSDIS QCVDNIRCNG LMMNAFEENS
KVTVPQMIKS DASLYCDDVD IRFSKTMNSC KVLQIRYASV ERLLERLTDL RFLSIDFLNT
FLHSYRVFTT AVVVLDKLIT IYRKPISAIP ARSLELLFAS GQNNKLLYGD PPKSPRATRK
FSSPPPLSIT KTSSPSRRRK LSLNIPIITG GKALDLAALS CNSNGYTSMY SAMSPFSKAT
LDTSKLYVSS SFASKIPDEG DMSTEKPEES SAPSKQGSEV SMREESDNDQ NQSDEGDTET
SPTKSPTTPK SVKSKNSSEF PLFSYNNGVV MTSCRELDSN RSALSAASAF AIATAGANEG
TPNKEKYRRM SLASAGFPPD QRNGDKEFVI RRAATNRVLN VLRHWVSKHS QDFETNDELK
CKVISFLEEV MHDPELLTQE RKAAANIIRT LTQDDPGDSQ ITLEELTQTA EGVKAEPFEN
HSALEIAEQL TLLDHLVFKK IPYEEFFGQG WMKLEKNERT PYIMKTTKHF NDISNLIASE
IIRNEDINAR VSAIEKWVAV ADICRCLHNY NAVLEITSSM NRSAIFRLKK TWLKVSKQTK
TLIDKLQKLV SSEGRFKNLR EALKNLNRMP AEGAQGPGSH CQLLPGKPSR LFPSVEDGNS
SGGASLLADQ QVTTQPPPNG GEHPSIYVDM MDPESWSSRV SGAPTRPNTR FHLYFLSVAT
EQSPVSC
//
