ID A0A2Y9LZQ6_DELLE Unreviewed; 369 AA.
AC A0A2Y9LZQ6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Apolipoprotein A-V {ECO:0000256|ARBA:ARBA00040758};
DE AltName: Full=Apolipoprotein A5 {ECO:0000256|ARBA:ARBA00042594};
GN Name=APOA5 {ECO:0000313|RefSeq:XP_022414915.1,
GN ECO:0000313|RefSeq:XP_022414917.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022414915.1};
RN [1] {ECO:0000313|RefSeq:XP_022414915.1, ECO:0000313|RefSeq:XP_022414917.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022414915.1,
RC ECO:0000313|RefSeq:XP_022414917.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with GPIHBP1 (By similarity). Interacts with SORL1;
CC this interaction leads to APOA5 internalization and sorting either to
CC lysosomes and degradation, or to the trans-Golgi network.
CC {ECO:0000256|ARBA:ARBA00038829}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}. Late endosome
CC {ECO:0000256|ARBA:ARBA00004603}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR RefSeq; XP_022414915.1; XM_022559207.1.
DR RefSeq; XP_022414917.1; XM_022559209.1.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 1.20.120.20; Apolipoprotein; 2.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF13; APOLIPOPROTEIN A-V; 1.
DR Pfam; PF01442; Apolipoprotein; 1.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; HDL {ECO:0000256|ARBA:ARBA00022850};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..369
FT /note="Apolipoprotein A-V"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041069757"
FT REGION 314..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 160..187
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 369 AA; 41606 MW; A2264AFCE24301B9 CRC64;
MTSVAAVLTW ALALLSVLSI TQARKGFWDY FSQSSTDKGR VEQIQQQKLA REPTSLKDRL
EPDVSNMNFL EKLGPLNGQG REPPGLPHDP VGMRQQLQEE LEEVRERLEP YMAEVHERVG
WHLEGLRRQL QPYTVELMEQ VALRVQELQE QLRVVGEGTK AQLLGGVEEA RSLLQELQDR
VANHTGRVKA LFHPYAERLV TGIGHHVQEL HRSVAPHAAA SPARLSRCVQ VLSRKLTLKA
KALHTRIQQN LDQLREELSV FAGAGADGAE EEAQPDPQVL SQEVRQRLQA FRHDTFLQIA
AFTRAIDQET KQIQQQLAPP PPGHSAFAPE FLQGDRGKAR SELQARLDDL WEDINYSLRD
HSPGHLGEP
//
