ID A0A2Y9LZR6_DELLE Unreviewed; 4130 AA.
AC A0A2Y9LZR6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PRKDC {ECO:0000313|RefSeq:XP_022412527.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022412527.1};
RN [1] {ECO:0000313|RefSeq:XP_022412527.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022412527.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022412527.1; XM_022556819.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_022412527.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2881..3541
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3724..4055
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4098..4130
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2662..2724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2705..2724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4130 AA; 464091 MW; 1DA88FCE0B6BE90C CRC64;
MADAGSGVRG TLLQLQESLS AADCCGAAVA SCQLLRGLGQ ECVLSSGPAL LALHTSLVFS
KDFGLLVFVR KSLSVDEFRD CREEALKFLC VFLEKIGQKV THYSLDIKNT CTSVYTKDKA
AKCKIPALEL LIKLLQTLRS SSLMDEFRVG ELFSKFYGEL ALKTKIPDTV LEKIYELLGV
LGEVHPSEMV NNSDKLFRAF LGELKTQMTS TVREPKLPVL AGCLKGLASL LCNFTKSMEE
DPQTSREIFD FALKAICPQI DLKRYAVPLA GLSIFTLHAS QFSTCLLDNY VSLFEILSKW
CSHTNTELKK AAYSALESFL KQLSFMVANN AETHRSKLRY FMEQFYGIIR NVDANSKDLS
IAVRGYGLFA GPCKVINAED VGFMFVELVQ RCRQLFLTET DTAEDHVYQM PSFLQSVASV
LLHLDTVPEV HMPVLEHLVV VQIDSFPQYG PKMQLVCCKA IVKVFLALAE KGPVLWNCIS
TVVHQGLIRI CSKPVILQKG TEPESEDCCV SGEARTGKWR VPTYKDYLDL FRNLLSCDQM
TDSLLADEAF LFVNSSLPSL NRLLYDEFVK SVLKIIEKLD LTLEKQSVGE QEHENEAAGV
WVSPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKHVE FFEPWVCSFA YELILQSTRL
PFISGFYKLL SIAVRNAKKI KYFEGVGPKS QKQSSEDPEK SFCFALFAKF GKEVSVKMKQ
YKDELLASCL TFVLSLPHDI IELDVRAYVP ALQMAFKLGL SYTPLAEVGL NALEEWSVYI
GKHVIQPYYK DILPSLDGYL KTSALSDETR NNWEVSALSR AAQKGFTRDV LKHLKRAKNV
SSHEALSLEE IRVRVVQVLG RLGGQISKNL ITVSPEERAR RCVAWDRERR LGFAVPFADM
KPIIHLDPFL PRVTELALSA ADRQTKVAAC ELLHSIVMFM LGKATQMPDS GLGPPPMYQL
YKRTFPVLLR LACDVDQVPR QLYEPLVMQL IHWFTNNKKF ESQDTVALLE TILDGIVDPF
DSTLRDFCGR CIQEFLKWSI KQTTPQQQEN SPVNTKSLFK RLYSFALHPN AFKRLGASLA
FNNIYREFRE EESLVEQFVF EALVTYVESL ALAHADERSL AGTVQQCCDA IDHLGRIVEK
KHVSLNKAKK RRCPRGFPPT APLCLSDVVQ WLFSNCGRPQ TECRHKSIEL FYKFVPLLPG
NKSPSLWLRD LIQKEGISFL INAFEGGGAC DPPAGILTQP TLLQLRGPFS LRATLQWMDT
LLAALECYNT FLGAGTLGAA QLLGAETQSS LWKAVAFFLE SIALHDITAA EKCFGAGAAG
DRPSPSEGER YNYSKCTVVV RVLEFSTTLL GTSPDSWKLL GKDSCSADLT KLLVRMLCAP
SSVGFNVGDF PVMDHLPSVC VGLLKALKMS PHCAALEACL REEVTTRSIE ELCAVDLYGL
DAHASRAELA SVVSACKQLH RAGFLHVIAP SQSADQPHSL GTKLLSLVYK SIAPGVEGQC
LPSLDPSCKR LANGLLELAF ACGGLCEHLV GLLLDTAVVS MPSSGGSQRN IVSFSHGQYF
YSLFSETINT ELLKNLDVAV LVLMKSSVDN PKMVSAILNG LLDQSFRDRA SQKHQGLKLV
GAILQSWRSC GPWWARDAAP DSKMAVLTLL AKILQIDSSV SFNTNHSAFP EVFTTYVSLL
ADPNLGLHLK GQAVILLPFF TSLTGGHLQE LKHVLGKLIV SNFPMKSEEF PPGTLRYNNY
ADCMKKLLDA LELSQSPVLL ELMTEILCRE QQHVMEELFQ STFRKIARKS SCATQLGLLD
SVYGMFRRDD LLPSVTRQAT VDRVLLTLLW HCDLSALRDF FSSIVVDAID VLKSRFIKLN
ESSFDTQITK KMGYYKLLDV MYSRLPKGDV HSKESKINQV FHGSRVPEGN ELTKTLIKLC
HNAFTENMAG EAQLLERRRL YHCAAYNCAI AAIRCVFTEL KFYQGFLFSE KPEKNLLIFE
NLIDLKRCYT FPIEVEVPME RKKRYIEIRR EAREAANGDS GGPCYMSSLS YLADSSLSEE
MSQFDFCTGV QSYSYGSQDP QSTAGRFWRR ERPDPEAPGD VLELEMDELN RHECMAPMAA
LVRHMQRLQA TQPEEGSVPR SLPPWMKFLH DKLGDPSVSL NIRLFLAKLV VNTEEVFRPH
AKHWIGPLLQ LVVSENNVGG GIHYMVVEIV ATVLSWTGVA TPVGVPKDEV LANRLLHFLM
KHVFHQKRAV FRHNLEIIKT LVECWKDCLS IPYRLMFEKF SSKDPNSKDN SIGIQLLGIV
MANDLPPYDP KCGIESVRYF QPLVNNMSFV KYKEVYAAAA EVLGLILRHL TGREKTLEES
VCEMVVKQLK RHQHTAEDKF IVCLNRAAKN FPPLADRFMS SVLLLLPRAH GVMKTLCLEV
VLCRADERAD LYLQLESRGF AQLMRHRDDE RQKVCLDIIY KLMARLKPVE LRGLLSPVAE
FLSHPSALCR EQMYSILMWV HDNYRDPESQ ADVDSQEAFK LAKDVLIQGL TDENPGLQLM
IRNFWSHETR LPSNTLDRLL ALNSLYSPKI EVRFLSLATD FLLEMTSVSP DFRSPVFEHP
LSECEFQEYS IDPDWRCRSV VLTPMFLETQ ASQSALQTRT QDGTLSARRG LAGQVRATQQ
QLDFTPTQSA GGRGSCHWLT GGSIDPLGDG SAPATESSPS SSSLLFAHKR PEGLRGAAPK
SVGPDFGKKR LRLPGDEVDN GTKGPDNRAE ILRLRRRFLK DREKLSLIYA RKGVAEQKRE
KEMKSELKMK REAHVVLYRS YRRGDLPDIQ IPHSSLITPL QAVAQRDPLI AKQLFSSLCS
GILKEMDKHR TASERRGATQ KLLQDFTHLL STTFLFFPPF VSCIQEVSCR HADLLSLDPA
VVGSAGLAGL QQPGAIHLLE EALLHLLPQE PPAKRARGRP GLPATVGRWM ELARLYRSIG
EYDTLRGIFS SEIGTKQITQ DALLAEARSD YSEAARLYNE ALNRQEWADG EPAEAEKDFW
ELASLECYNQ LADWKSLAYC STASADGEGA PDLSRMWSEP FCQETCLPHM IRSRLKSLLR
GEGDQTLLTF VDEAVTSELR RALLELRYSQ ELSLLYLLQD DVDRAEYYIR NCIQMFLQNY
SSIDVLLHRS RLTKLQSVQT FIEIQEFISF ISKEGNLSSH LPLKRLLKTW TSRYPDAKMD
PMNVWDDIIT NRCFFLSKIE EKLTLLPDDG GVSEDADGMG VQALEEDARS LIASCKFSMR
LQMVESARKQ NNFSLALKLL KELHRESKTR EDWLVKWVQS YCRLSHGRAR AQRPPEQLCA
ALKTVPLLAG ENTSSYLSRN VVASRDHNIL VGTAYKIMAD ALSSEPTCLA GIEESKARSV
MELSGSSSED AEKVAAGLYQ RAFHHLSEAV RTAAQEEAGR SARGQEPACG LVAAYLALAE
FCDQRLRKQE EGAPVLDAAE LRTYPALVVD KMLKALKLHS SEARLKFPRL LQIVEQYPEE
TLSLMTREIS SIPCWHFIGW ISHMVALLDK EEGVAVQRTV ADIADHYPQA VVYPFMISSE
SYAFRDTSAG HKNKDFVARI KAKLDREGVV QDFINALEQL SSPEMLFKDW TEDVKLELEK
NPVNKKNLER MYERMYAALG DPQAPGLGSF RRRFIQAFGK EFDEHFGRGG SKLPGMRLQD
FRSITSLLLG RMSRASKVPG NLKECSPWMS SFRAEFLRDE LEVPGQYDGR GKPMPEYHAR
IAGFDERVKV MASLRRPMRI VVRGHDEREY AFLVKGGEDL RQDQRVCQLL QVMNGVLARD
AACGQRGLQV TTYRVVPMTS RLGLIEWIEG TCTLKELLLS SMSREEKAAY TSDPRAPASE
YRDWLRRMSG RCDPGAYALM FKGASRTETV TSFRKRESKV PADLLKRAFL KMSTGPEAFL
ALRNHFASSH ALLCVSHWIL GIGDRHLNNF MVSLETGGVI GIDFGHAFGS ATQFLPVPEL
MPFRLTRQFI TLMLPLKETG LVGSTMVCAL RAFRSRPDLL TTAMDVFVKE PSFDWKNFEQ
KMLRKGGSWI QEINVTEKNW YPRQKIHHAK RKLAGANPAV ITCDELLLGH EKVPAFEHYI
AVAQGSRDHN IRAQEPSSGL SEEAQVKCLI DQATDPNILG RTWEGWEPWM
//