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Database: UniProt
Entry: A0A2Y9LZR6_DELLE
LinkDB: A0A2Y9LZR6_DELLE
Original site: A0A2Y9LZR6_DELLE 
ID   A0A2Y9LZR6_DELLE        Unreviewed;      4130 AA.
AC   A0A2Y9LZR6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=PRKDC {ECO:0000313|RefSeq:XP_022412527.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022412527.1};
RN   [1] {ECO:0000313|RefSeq:XP_022412527.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022412527.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC       {ECO:0000256|ARBA:ARBA00011031}.
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DR   RefSeq; XP_022412527.1; XM_022556819.2.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR   GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR   CDD; cd05172; PIKKc_DNA-PK; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR037706; DNA-PK_dom.
DR   InterPro; IPR046804; DNA-PKcs_N.
DR   InterPro; IPR046803; DNAPKcs_CC1-2.
DR   InterPro; IPR012582; DNAPKcs_CC3.
DR   InterPro; IPR045581; DNAPKcs_CC5.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR   Pfam; PF20500; DNA-PKcs_N; 1.
DR   Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR   Pfam; PF08163; DNAPKcs_CC3; 1.
DR   Pfam; PF19704; DNAPKcs_CC5; 1.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM01344; NUC194; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_022412527.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          2881..3541
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
FT   DOMAIN          3724..4055
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   DOMAIN          4098..4130
FT                   /note="FATC"
FT                   /evidence="ECO:0000259|PROSITE:PS51190"
FT   REGION          2662..2724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2705..2724
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4130 AA;  464091 MW;  1DA88FCE0B6BE90C CRC64;
     MADAGSGVRG TLLQLQESLS AADCCGAAVA SCQLLRGLGQ ECVLSSGPAL LALHTSLVFS
     KDFGLLVFVR KSLSVDEFRD CREEALKFLC VFLEKIGQKV THYSLDIKNT CTSVYTKDKA
     AKCKIPALEL LIKLLQTLRS SSLMDEFRVG ELFSKFYGEL ALKTKIPDTV LEKIYELLGV
     LGEVHPSEMV NNSDKLFRAF LGELKTQMTS TVREPKLPVL AGCLKGLASL LCNFTKSMEE
     DPQTSREIFD FALKAICPQI DLKRYAVPLA GLSIFTLHAS QFSTCLLDNY VSLFEILSKW
     CSHTNTELKK AAYSALESFL KQLSFMVANN AETHRSKLRY FMEQFYGIIR NVDANSKDLS
     IAVRGYGLFA GPCKVINAED VGFMFVELVQ RCRQLFLTET DTAEDHVYQM PSFLQSVASV
     LLHLDTVPEV HMPVLEHLVV VQIDSFPQYG PKMQLVCCKA IVKVFLALAE KGPVLWNCIS
     TVVHQGLIRI CSKPVILQKG TEPESEDCCV SGEARTGKWR VPTYKDYLDL FRNLLSCDQM
     TDSLLADEAF LFVNSSLPSL NRLLYDEFVK SVLKIIEKLD LTLEKQSVGE QEHENEAAGV
     WVSPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKHVE FFEPWVCSFA YELILQSTRL
     PFISGFYKLL SIAVRNAKKI KYFEGVGPKS QKQSSEDPEK SFCFALFAKF GKEVSVKMKQ
     YKDELLASCL TFVLSLPHDI IELDVRAYVP ALQMAFKLGL SYTPLAEVGL NALEEWSVYI
     GKHVIQPYYK DILPSLDGYL KTSALSDETR NNWEVSALSR AAQKGFTRDV LKHLKRAKNV
     SSHEALSLEE IRVRVVQVLG RLGGQISKNL ITVSPEERAR RCVAWDRERR LGFAVPFADM
     KPIIHLDPFL PRVTELALSA ADRQTKVAAC ELLHSIVMFM LGKATQMPDS GLGPPPMYQL
     YKRTFPVLLR LACDVDQVPR QLYEPLVMQL IHWFTNNKKF ESQDTVALLE TILDGIVDPF
     DSTLRDFCGR CIQEFLKWSI KQTTPQQQEN SPVNTKSLFK RLYSFALHPN AFKRLGASLA
     FNNIYREFRE EESLVEQFVF EALVTYVESL ALAHADERSL AGTVQQCCDA IDHLGRIVEK
     KHVSLNKAKK RRCPRGFPPT APLCLSDVVQ WLFSNCGRPQ TECRHKSIEL FYKFVPLLPG
     NKSPSLWLRD LIQKEGISFL INAFEGGGAC DPPAGILTQP TLLQLRGPFS LRATLQWMDT
     LLAALECYNT FLGAGTLGAA QLLGAETQSS LWKAVAFFLE SIALHDITAA EKCFGAGAAG
     DRPSPSEGER YNYSKCTVVV RVLEFSTTLL GTSPDSWKLL GKDSCSADLT KLLVRMLCAP
     SSVGFNVGDF PVMDHLPSVC VGLLKALKMS PHCAALEACL REEVTTRSIE ELCAVDLYGL
     DAHASRAELA SVVSACKQLH RAGFLHVIAP SQSADQPHSL GTKLLSLVYK SIAPGVEGQC
     LPSLDPSCKR LANGLLELAF ACGGLCEHLV GLLLDTAVVS MPSSGGSQRN IVSFSHGQYF
     YSLFSETINT ELLKNLDVAV LVLMKSSVDN PKMVSAILNG LLDQSFRDRA SQKHQGLKLV
     GAILQSWRSC GPWWARDAAP DSKMAVLTLL AKILQIDSSV SFNTNHSAFP EVFTTYVSLL
     ADPNLGLHLK GQAVILLPFF TSLTGGHLQE LKHVLGKLIV SNFPMKSEEF PPGTLRYNNY
     ADCMKKLLDA LELSQSPVLL ELMTEILCRE QQHVMEELFQ STFRKIARKS SCATQLGLLD
     SVYGMFRRDD LLPSVTRQAT VDRVLLTLLW HCDLSALRDF FSSIVVDAID VLKSRFIKLN
     ESSFDTQITK KMGYYKLLDV MYSRLPKGDV HSKESKINQV FHGSRVPEGN ELTKTLIKLC
     HNAFTENMAG EAQLLERRRL YHCAAYNCAI AAIRCVFTEL KFYQGFLFSE KPEKNLLIFE
     NLIDLKRCYT FPIEVEVPME RKKRYIEIRR EAREAANGDS GGPCYMSSLS YLADSSLSEE
     MSQFDFCTGV QSYSYGSQDP QSTAGRFWRR ERPDPEAPGD VLELEMDELN RHECMAPMAA
     LVRHMQRLQA TQPEEGSVPR SLPPWMKFLH DKLGDPSVSL NIRLFLAKLV VNTEEVFRPH
     AKHWIGPLLQ LVVSENNVGG GIHYMVVEIV ATVLSWTGVA TPVGVPKDEV LANRLLHFLM
     KHVFHQKRAV FRHNLEIIKT LVECWKDCLS IPYRLMFEKF SSKDPNSKDN SIGIQLLGIV
     MANDLPPYDP KCGIESVRYF QPLVNNMSFV KYKEVYAAAA EVLGLILRHL TGREKTLEES
     VCEMVVKQLK RHQHTAEDKF IVCLNRAAKN FPPLADRFMS SVLLLLPRAH GVMKTLCLEV
     VLCRADERAD LYLQLESRGF AQLMRHRDDE RQKVCLDIIY KLMARLKPVE LRGLLSPVAE
     FLSHPSALCR EQMYSILMWV HDNYRDPESQ ADVDSQEAFK LAKDVLIQGL TDENPGLQLM
     IRNFWSHETR LPSNTLDRLL ALNSLYSPKI EVRFLSLATD FLLEMTSVSP DFRSPVFEHP
     LSECEFQEYS IDPDWRCRSV VLTPMFLETQ ASQSALQTRT QDGTLSARRG LAGQVRATQQ
     QLDFTPTQSA GGRGSCHWLT GGSIDPLGDG SAPATESSPS SSSLLFAHKR PEGLRGAAPK
     SVGPDFGKKR LRLPGDEVDN GTKGPDNRAE ILRLRRRFLK DREKLSLIYA RKGVAEQKRE
     KEMKSELKMK REAHVVLYRS YRRGDLPDIQ IPHSSLITPL QAVAQRDPLI AKQLFSSLCS
     GILKEMDKHR TASERRGATQ KLLQDFTHLL STTFLFFPPF VSCIQEVSCR HADLLSLDPA
     VVGSAGLAGL QQPGAIHLLE EALLHLLPQE PPAKRARGRP GLPATVGRWM ELARLYRSIG
     EYDTLRGIFS SEIGTKQITQ DALLAEARSD YSEAARLYNE ALNRQEWADG EPAEAEKDFW
     ELASLECYNQ LADWKSLAYC STASADGEGA PDLSRMWSEP FCQETCLPHM IRSRLKSLLR
     GEGDQTLLTF VDEAVTSELR RALLELRYSQ ELSLLYLLQD DVDRAEYYIR NCIQMFLQNY
     SSIDVLLHRS RLTKLQSVQT FIEIQEFISF ISKEGNLSSH LPLKRLLKTW TSRYPDAKMD
     PMNVWDDIIT NRCFFLSKIE EKLTLLPDDG GVSEDADGMG VQALEEDARS LIASCKFSMR
     LQMVESARKQ NNFSLALKLL KELHRESKTR EDWLVKWVQS YCRLSHGRAR AQRPPEQLCA
     ALKTVPLLAG ENTSSYLSRN VVASRDHNIL VGTAYKIMAD ALSSEPTCLA GIEESKARSV
     MELSGSSSED AEKVAAGLYQ RAFHHLSEAV RTAAQEEAGR SARGQEPACG LVAAYLALAE
     FCDQRLRKQE EGAPVLDAAE LRTYPALVVD KMLKALKLHS SEARLKFPRL LQIVEQYPEE
     TLSLMTREIS SIPCWHFIGW ISHMVALLDK EEGVAVQRTV ADIADHYPQA VVYPFMISSE
     SYAFRDTSAG HKNKDFVARI KAKLDREGVV QDFINALEQL SSPEMLFKDW TEDVKLELEK
     NPVNKKNLER MYERMYAALG DPQAPGLGSF RRRFIQAFGK EFDEHFGRGG SKLPGMRLQD
     FRSITSLLLG RMSRASKVPG NLKECSPWMS SFRAEFLRDE LEVPGQYDGR GKPMPEYHAR
     IAGFDERVKV MASLRRPMRI VVRGHDEREY AFLVKGGEDL RQDQRVCQLL QVMNGVLARD
     AACGQRGLQV TTYRVVPMTS RLGLIEWIEG TCTLKELLLS SMSREEKAAY TSDPRAPASE
     YRDWLRRMSG RCDPGAYALM FKGASRTETV TSFRKRESKV PADLLKRAFL KMSTGPEAFL
     ALRNHFASSH ALLCVSHWIL GIGDRHLNNF MVSLETGGVI GIDFGHAFGS ATQFLPVPEL
     MPFRLTRQFI TLMLPLKETG LVGSTMVCAL RAFRSRPDLL TTAMDVFVKE PSFDWKNFEQ
     KMLRKGGSWI QEINVTEKNW YPRQKIHHAK RKLAGANPAV ITCDELLLGH EKVPAFEHYI
     AVAQGSRDHN IRAQEPSSGL SEEAQVKCLI DQATDPNILG RTWEGWEPWM
//
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