ID A0A2Y9LZY7_DELLE Unreviewed; 226 AA.
AC A0A2Y9LZY7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Interleukin-7 {ECO:0000256|ARBA:ARBA00019460};
GN Name=IL7 {ECO:0000313|RefSeq:XP_022410708.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022410708.1};
RN [1] {ECO:0000313|RefSeq:XP_022410708.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022410708.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with IL7R and CSF2RG.
CC {ECO:0000256|ARBA:ARBA00034136}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family.
CC {ECO:0000256|ARBA:ARBA00007621}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022410708.1; XM_022555000.2.
DR AlphaFoldDB; A0A2Y9LZY7; -.
DR STRING; 9749.A0A2Y9LZY7; -.
DR KEGG; dle:111164935; -.
DR InParanoid; A0A2Y9LZY7; -.
DR OrthoDB; 4630779at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 1.20.1250.50; -; 2.
DR InterPro; IPR001181; IL-7.
DR InterPro; IPR018049; IL-7/IL-9_CS.
DR InterPro; IPR038325; IL7_sf.
DR PANTHER; PTHR48404; INTERLEUKIN-7; 1.
DR PANTHER; PTHR48404:SF1; INTERLEUKIN-7; 1.
DR Pfam; PF01415; IL7; 1.
DR PRINTS; PR00435; INTERLEUKIN7.
DR SMART; SM00127; IL7; 1.
DR PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..226
FT /note="Interleukin-7"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015846734"
FT REGION 169..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 25720 MW; 308C307FC21FC983 CRC64;
MFHVSFRYIF GIPPLILVLL PVASSDCDIE GKDGGAYQNV LMVNINDLHT FTNIRSDVQV
SKDAASALYI KWHKKMGLCF LVFVPLSSLA EDFAHWPVDS MIDFDSNCLN NEPNFFKKHS
CDDNKEASFL YRAARKLKQF LKMNISDDFN LHLSTVSQGT LTLLNCTNKG KGRKSTSLGE
AQPTKNLEEN KSLKEQKKQN DLCFLKILLQ KIKTCWNRIL RGAKEH
//
