ID A0A2Y9M0P2_DELLE Unreviewed; 679 AA.
AC A0A2Y9M0P2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Transducin-like enhancer protein 2 isoform X5 {ECO:0000313|RefSeq:XP_022412837.1};
GN Name=TLE2 {ECO:0000313|RefSeq:XP_022412837.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022412837.1};
RN [1] {ECO:0000313|RefSeq:XP_022412837.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022412837.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR RefSeq; XP_022412837.1; XM_022557129.1.
DR AlphaFoldDB; A0A2Y9M0P2; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF4; TRANSDUCIN-LIKE ENHANCER PROTEIN 2; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 1..63
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 479..520
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 521..562
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 603..634
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 110..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 72103 MW; 7F585FB124934BC7 CRC64;
MSYGLNIEMH KQAEIVKRLS GICAQIIPFL TQEHQQQVLQ AVERAKQVTV GELNSLIGQQ
QLQPLSHHAP PVPLTPRPAG LVGGSATGLL ALSGALAAQA QLAAVAKEDR TGVEAEGSRV
ERAPSRSASP SPPESVAEEE RPSGPGGNGK QRAEEKDLSG PYESDEDKSD YNLVVDEDQP
SEPPSPATTP CGKAPICIPA RRDLVDSPAS LASSLGSPLP RTKELVLNDL PAGTPASKSS
DSSPPQDAST PGPSSASHLR QLAAKPAPST DSIALRSPLT LSSPFTTSFS LGSHSALNGD
LSVPSSYVSL HLSPQVSGSV MYGRSPMMAF ESHPHLRGSS ISSSLPTIPG GKPAYSFHVS
ADGQMQPVPF PSDALVGAGI PRHARQLHTL AHGEVVCAVT ISGTTQHVYT GGKGCVKVWD
VGQPGAKTPV AQLDCLNRDN YIRSCKLLPD GRSLIVGGEA STLSIWDLAA PTPRIKAELT
SSAPACYALA VSPDAKVCFS CCSDGNIVVW DLQNQTMVRQ FQGHTDGASC IDISDYGTRL
WTGGLDNTVR CWDLREGRQL QQHDFSSQIF SLGHCPNQDW LAVGMESSNV EILHVRKPEK
YQLHLHESCV LSLKFASCGR WFVSTGKDNL LNAWRTPYGA SIFQSKESSS VLSCDISGNN
KYIVTGSGDK KATVYEVVY
//
