ID A0A2Y9M0S3_DELLE Unreviewed; 4543 AA.
AC A0A2Y9M0S3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Plectin isoform X9 {ECO:0000313|RefSeq:XP_022410978.2};
GN Name=LOC111165064 {ECO:0000313|RefSeq:XP_022410978.2};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022410978.2};
RN [1] {ECO:0000313|RefSeq:XP_022410978.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022410978.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022410978.2; XM_022555270.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd21238; CH_PLEC_rpt2; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF20; PLECTIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 18.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 33.
DR SMART; SM00150; SPEC; 6.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 5.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..157
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 170..275
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1479..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1768..1787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1953..1999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2064..2160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2531..2562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2604..2637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4470..4543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 396..423
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 727..776
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1118..1162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1234..1288
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1656..1686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2073..2115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2543..2562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4470..4524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4543 AA; 516205 MW; 66F1DEA3D7017088 CRC64;
MEPSGSLFPS LVVVGHVVTL AAVWHWHRGR RRAQDEQDER DRVQKKTFTK WVNKHLIKAQ
RHISDLYEDL RDGHNLISLL EVLSGDSLPR ERDVIRSSRL PREKGRMRFH KLQNVQIALD
YLRHRQVKLV NIRNDDIADG NPKLTLGLIW TIILHFQISD IQVSGQSEDM TAKEKLLLWS
QRMVEGFQGL RCDNFTSSWR DGRLFNAIIH RHKPTLIDMN KVYRQTNLEN LDQAFSVAER
DLGVTRLLDP EDVDVPQPDE KSIITYVSSL YDAMPRVPDV QDGVKANELQ LRWQEYRELV
LLLLQWIRAH TAGFEERRFP SSFEEIEILW CQFLKFKETE LPAKEADKNR SKGIYQSLEG
AVQAGQLKMP PGYHPLDVEK EWGKLHVAIL EREKQLRSEF ERLERLQRVV SKLQMEAGLC
EEQLNQADAL LQSDVRLLAS GKAPQRAGEL ERDLDKADSM IRTLFNDVQT LKDGRHPQGE
QMYRRVYRLH ERLVAIRTEY NLRLRSTPRH PELEDSTLRY LQDLLAWVEE NQRRLDSAEW
GVDLPSVEAQ LGSHRGLHQS VEEFRTKIER ARTDEGQLSP ATRGAYRDCL GRLDLQYARL
LSSSKARLRS LESLHGFVAA ATKELMWLSD REEEEVGFDW SDRNTNMAAK KEGYSALMHE
LELKEKKIKE IQGTGDRLLR EDHPARPTAE SFQAALQTQW SWMLQLCCCI EAHLKDNTAY
FQFFSDVREA EEQLRKLQET LRRKYTCDRS ITVTRLEDLL QDAQDEKEQL NEYRGHLSGL
AKRAKAIVQL KPRNPAHPVR GRVPLLAVCD YKQVEVTVHK GDECQMVGPA QPFYWKVLSS
SRSEATVPSV CFLVPPPNQE AQEAIARLEA QHQALVALWH QLHTEMKSLL AWQSLSRDMQ
LIRSWSLVTF RTLKPEEQRQ ALRSLELHYQ AFLRDSQDAA GFGPEDRLQA EREYGSCSRH
YQQLLQSLEQ DEQESSRCQR CISELKDIRL QLEACETRTV HRLRLPLDKE PARECAQRIT
EQQKAQAEVE GLGKGVARLS AEAEKVLALP EPSPAAPTLR SELELTLGKL EQVRSLSAIY
LEKLKTISLV IRSTQGAEEV LRAREEQLKE AQAVPATLPE LEATKAALKK LRAQAEAQQP
VFDALRDELR GAQEVGERLQ QRHGERDVEV ERWHERVALL LERWQAVLAQ TDVRQRELEQ
LGRQLRYYRE SADPLGAWLQ DAKQRQEQIQ AVPLANSQAV REQLRQEKAL LEDIERHGEK
VEECQRFAKQ YINAIKDYEL QLVTYKAQLE PVASPAKKPK VQSGSESVIQ EYVDLRTRYS
ELSTLTSQYI KFIGETLRRM EEEERLAEQQ RAEERERLAE VEAALEKQRQ LAEAHAQAKA
LAEREAQELQ RRMQEEVARR EEVAVDAQQQ KRSIQEELQH LRQSSEAEIQ AKARQVEAAE
RSRLRIEEEI RVVRLQLEAT ERQRGGAEGE LQALRARAEE AEAQKRQAQE EAERLRRQVQ
DETQRKRQAE AELALRVQAE AEAAREKQRA LQALEELRLQ AEEAERRLRQ AEAERARQVQ
VALETAQRSA EAELQSEHAS FAEKTAQLER TLKEEHVAVV QLREEATRRA QQQAEAERAR
AEAERELERW QLKANEALRL RLQAEEVAQQ KSLAQAEAEK QKEEAEREAR RRGKAEEQAV
RQRELAEREL EKQRQLAEGT AQQRLAAEQE LIRLRAETEQ GEQQRQLLEE ELARLQREAA
AATQKRQELE AELANVRAEM EVLLASKARA EEESRSTSEK SKQRLEAEAG RFRTLAEEAA
RLRALAEEAK RQRQLAEDDA VRQRAEAERV LAEKLAAISE ATRLKTEAEI ALKEKEAENE
RLRRLAEDEA FQRRLLEEQA AQHKADIEER LAQLRKASES ELERQKGLVE DTLRQRRQVE
EEILALKGSF EKAAAGKAEL ELELGRIRGN AEDTLRSKEQ AEQEAARQRQ LAAEEQRRRR
EAEERVQKSL AAEEEAARQR KAALEEVERL KAKVEEARRL RERAEQESAR QLQLAQEAAQ
KRLQAEEKAH AFAVRQKEQE LQQTLQQEQS MLERLRSEAE AARRAAEEAE AARERAEHEA
AQSRRQVEEA ERLKQSAEAQ AQVQAQAQAA AEKLRKEAEQ EAARRAQAEQ VALRQKQAAD
AEMEKHKQFA EQALRQKAQV EQELTALRLQ LEETDHQKSI LDEELQRLKA EVTEAARQRG
QVEEELFSLR VQMEELGKLK ARIEAENRAL VLRDKDNTQR LLQEEAEKMK QVAEEAARLS
VAAQEAARLR QLAEEDLVQQ RALAEKMLKE KMQAVQEATR LKAEAELLQQ QKELAQEQAR
RLQEDKEQMA QQLAQETQGF QKTLETERQR QLEMSAEAER LRLRVAEMSR AQARAEEDAQ
RFRKQAEEIG DRLYRTELAT QEKVTLVQTL ETQRQQSDQD AERLREAIAE LEREKDKLKQ
EAQLLQLKSE EMQVVRQEQL LQETQALQQS FLSEKDSLLQ REHLIEQEKA KLEQLFQDEV
AKAQQLREEQ QRQQQKLQQE KEQLAASMEE ARRRQREAEE GVRRKQEELR CLELQRQEQE
KLLAEENQRL RERLQHLEEE RRAALAHPGE VAPSQAAAAR ALPNGQDAAD GPAAVAEPEH
AFDGLRQKVP AQRLQEAGIL SAEELQRLAQ GRTTVAELAQ REDVRHYLQG RSSIAGLLLK
PADEKLSIYA ALRRHLLSPG TALILLEAQA ASGFLLDPVR NRRLAVNEAV KEGVVGPELH
HKLLAAERAV TGYKDPYTGE QISLFQAMKK DLIVREHGIR LLEAQIATGG IIDPVHSHRL
PVDVAYRRGY FDEEMNRVLQ DPSDDTKGFF DPNTHENLTY LQLLERCVED PETGLRLLLL
TDQAAKGGEL VYTDSEARDV FEKATVSAPF GKFQGRTVTI WELINSEYFT AEQRRDLLRQ
FRTGKVTVEK IIRIVITVVE EHEQKGQLCF EGLRALVPAA ELLESRVIDR ELFRQLQQGE
RSVQEVAEVE AVRRALRGSG VIAGVWLEEA GQKLSIYEAL RKDLLRPEAA VALLEAQAGT
GHIIDPTTSA RLTVDEAVRA GLVGPELHEK LLSAEKAVTG YKDPYSGQSV SLFQALKKGL
IPREQGLRLL DAQLSTGGIV DPSKSHRVPL DVACARGYLD KETSTALSAP EDNAKTYYEP
RTWQPVTYSH LQQQCRPDQL TGLSLLPLSE EAARARQQEL YSELQAHEAF QKATVEVPVG
SFQGRTVTVW ELISSEYFTA EQRQELLRQF RTGKVTVEKV IKILITIVEE VETVRQERLS
FSGLRAPVPA SELLAAGVLN STQYEQLKDG KTSVKDLSEL DSVRTLLQGS GCLAGVYLED
SKEKVTIYEA MRRGLLRPST ATLLLEAQAA TGFLVDPVRN QRLYVHEAVK AGVVGPELHE
KLLSAEKAVT GYKDPYSGST ISLFQAMKKG LVLREHGIRL LEAQIATGGI IDPVHSHRLP
VDVAYRRGYF DDEMNRVLQD PSDDTKGFFD PNTHENLTYV QLLERCVEDP ETGLRLLPLK
GAEKAEVVET TRVYTEEETR RAFEETEINI PGSGSHSGST MSLWEVMQSD LIPQEQRAQL
LADFQAGRVT KERMIIIVIE IIEKTEVVRS QSLASYGHVG RRITAENLYE ARVISRESYG
LLREGTRSLH EVLEAESAWH YLYGTGCVAG IYRSSSRQTL TIYQALKKGQ LSAEVARQLL
EAQAATGFLL DPVKGERLAV DEAVRKGLVG PELHDRLLSA ERAVTGYRDP YTEQTISLFQ
AMKKDLIPTE EALRLLDAQL ATGGIIDPRL GFHLPLEVAY QRGYLDKDTH DRLSEPSEVR
SYVDPSTDER LSYTQLLRRC RRDEASGQLL LPLADARKLT FRGLRKQITV EELVRSQVMD
EATALRLQEG LTSVEEVSKN LQKFLEGTSS IAGVLVDATK ERLSVYQAMK KGIIRPGTAF
ELLEAQAATG YVIDPIKGLK LTVEEAVRVG IVGPEFKDKL LSAERAVTGY KDPYSGKLIS
LFQAMKKGLI LKDHGIRLLE AQIATGGIID PEESHRLPVD VAYQRGLFDE EMNEILTDPS
DDTKGFFDPN TEENLTYLQL MERCVTDPQT GLRLLPLKEK KRERKTSSKS SVRKRRVVIV
DPETGKEMSV YEAYRKGLID HQTYLELSEQ ECEWEEITIS SSDGVVKSMI IDRRSGRQYD
IDEAIAKSLI DRSALDQYRA GTLSIAEFAD MLSGNAGGFR SRSSSVGSSS SYPISPAVSR
TQLVSWSDPT EETGPVAGIL DTETLEKVSI TEAMHRNLVD NITGQRLLEA QACTGGIIDP
STGERFPVTD AVNKGLVDKI MVDRINLAQK AFCGFEDPRT KTKMSAAQAL KKGWLYYEAG
QRFLEVQYLT GGLIEPDTPG RVALDEALQR GTVDARTAQK LRDVSAYSKY LTCPKTKLKI
SYKDALDRSM VEEGTGLRLL EAAAQSSKGY YSPYSISGSG SAAGSRSSSR TGSRAGSRRG
SFDATGSGFS MTFSSSSYSS SGYGRRYASG PAPSAGGPES AAA
//
