ID A0A2Y9M1X3_DELLE Unreviewed; 3024 AA.
AC A0A2Y9M1X3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Otogelin isoform X1 {ECO:0000313|RefSeq:XP_022411368.1};
GN Name=OTOG {ECO:0000313|RefSeq:XP_022411368.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022411368.1};
RN [1] {ECO:0000313|RefSeq:XP_022411368.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022411368.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_022411368.1; XM_022555660.1.
DR STRING; 9749.A0A2Y9M1X3; -.
DR KEGG; dle:111165230; -.
DR InParanoid; A0A2Y9M1X3; -.
DR OrthoDB; 2872912at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR CDD; cd19941; TIL; 5.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR036195; AbfB_ABD_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF228; OTOGELIN; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00215; VWC_out; 1.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF110221; AbfB domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 4.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..3024
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015872229"
FT DOMAIN 91..128
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 139..311
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 501..677
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 975..1143
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2112..2291
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT REGION 38..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1635..1773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1791..1811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2004..2042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1522..1537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1635..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1721..1737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1738..1756
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1791..1807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2017..2042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3024 AA; 324303 MW; 2EF92FB29430ED93 CRC64;
MGAPAPAFCL LVACVWLPRS EPAGESLPLQ PLAAAPAPWG NAELQPEPAQ DPSHSHQEAI
LAIGDATTVM GGQEAEALDS LAMSSWERRL HRAKCAPSYL FSCFNGGECV HPAFCDCRRF
NATGPRCQMV YNVGPERDSI CRAWGQHHVE TFDGLYYYLF GKGSYTLVGR HEPEGQTFSV
QVHNDPQCGS FPYTCSRSVS LFLAGEQEIH LAKEVTRGGI RVQLPHVMGS MRLQRLAGYV
LVRHQSAFTL AWDGTSAVYI KMSPEFLGWT HGLCGNNNAD PQDDLVTSYG KLTEDVAEFV
HSWQEQAPNQ PPGPTTSSLP RPPCLQQSLG TMQGVYDRCE ALLRPPFDAC HAYVSPLPFT
ASCTSDLCQS AGDEATWCRA LAEYARACAQ AGQPLQGWRN QLRPCAVHCK EKAFIYNECI
ACCPASCQPR ASCVDSEITC VDGCYCPDGL IFEDGGCVAP AECPCEFHGT LYPTGSVVKE
DCNTCTCTAG KWLCSTSVCP AECSVTGDIH FTTFDGRRYT FPATCQYILA KSRSSGTFTV
TLQNAPCGLN QDGVCVQSVS VILHQDPRRQ VTLTQAGDVL LFDQYKVTPP YTDDAFEIRR
LSSVFLRVRT NVGVRVLYDR EGPRLYLQVD QRWVEDTVGL CGTFNGNTQD DFLSPVGVPE
STPQLFGNSW KTLSACFPLV SGSPVDPCDV HLQAASYALQ SCSVLTGELF APCSAYLSPV
PYFEQCRRDT CRCGQPCLCA TLAHYARLCQ RHGLPVDFRA HLPACALSCE ATKEYSPCVA
PCGQTCQDLA GPEACGVDGG GDLSGDECVE GCACPPDTYL DTQADLCVPR NRCSCHFQGM
DYPPGDSDIP SLGHCHCKDG VMSCGSRAPA AACPAGQVFV NCSDLHTDPE LSRERTCEQQ
LLNLSLSVPA RGPCLSGCAC PQGLLRHGDA CFLPEECPCT WKGKEYFPGD QVMSPCHSCV
CQHGSFQCAL HPCASTCTAY GDRHYRTFDG LPFDFVGACK VHLVKSTSDF SFSVTVENVN
CYSSGITCRK FISINVGNSL IVFDDDSGNP SPESFLDEKQ EVHTWRAGFF TLVHFPREHV
TLLWDQRTTV HIQAGPQWQG QLAGLCGNFD LKTINEMRTP EKLELTNPQE FGGSWATVEC
PDTLDPRDTC VLNPLREPFA KKECSILLSE VFETCHPVVD VTWFYSNCLT DTCGCSRGGD
CECFCASVSA YAHQCCQHGV AVDWRTPHLC PHDCDFFNKA LGKGPYQLAS LAASGALVAM
KVAGAAIVLV RAEDVAPGDI VNFLLTAALY KAKAHDPDVI SLEAADRPNF FLHVMANGSL
ELAKWQASDA FHHHASFSLH SWRAGLVALE SLAEPGAFLY VLGPVLALRL YEHTEAFRRG
TLFRLLDAKR SGAPYPTCEW HYDACASPCF QTCQDPRAAS CQDVPRVEGC VPVCPTPRVL
DQVTQRCVYL EDCVEPMVLV PTEAFGNETL PPGQELPTPS DEELQFPQEA PGAPSHRPAP
TPAIPLTTAL NAPVAATEGP ALSPGPTQTT QKQPPGVTAF NVPEHPTEAP ASTGVTASHL
ATPRVPEPSS LPLSQQMPTS GMGSGAMETT RVTVIFAGSV NITVSSLSPP APRFPLVTKA
MTVLGLGSLP VKTTPLQPSP SLELPASPSS RPVASPAVTS RPPTSSGSHE ALPTPSITEV
MTGTGIPRPV QSQSISSPSS PPAESRTAAE QIPASPLVTE MVETAPSTEK VQPGPSQATG
PPASPLPSPF PTAPLHPAPH ATAAARPPAL PSGPVTAASL STVARGLGAT PFTSLESTRQ
PQLLSGLPPD TSLPLAKVGT SAPVATPGPS VSAIPPPLQQ QAASPAVATT LPARTLSPAL
PLTQAVLAQV HPPSHVVPQA TGTAPDLLLG ATLPASGVVA VALAGGVAST VSAAGPRKST
TEKMAILSEQ VSQPTWIYGS AQGGPTELTP AVAHTAATLV TEAEGPWAGT VPLVPTSYPL
SRVSARTASR ESSLVLLPQL AEAHGTSAGP QPQAEPEGEA TTEQSGRSAP AQSISAGPAE
SLATTTEAST SEICVPIAEQ DCVRHICLEG QLIRVNQSQH CPQGTAPPSC GVLGLAVRVG
GDRCCPFWEC ACRCSIFPDL SFVTFDGSYV ALFKEAIYIL SQSPDEMVTV HVLDCKSANL
GHLNWPPFCL VMLNVTHLTH QVTIDRFNRK VFVDLQPVWP PVSRYGFTIE DTGHMYVIRT
PSHIQIQWLH SSGLMILEAS KASQAQGRGL CGICDGDAAN DLTLEDGSVV GEAEDPAPFL
DSWQVPSSLT SVGQTRFRPD SCATADCSPC LRMVSNHTFS VCHRFVTPES FCELWIRDTK
YLQQPCVALT VYVAMCHKFH VCIKWRRSDY CPFLCPSDST YQACVAACEP PETCQDGLLG
PLDPEQCQVL GEGCVCSEGT ILHRRRSGFC IPEEKCACTD STGVPRALGE TWNSSLSGCS
QHQCQAPDTI VPVGPGCPDP RPEICPRFGE VALLLPTEDP CCLGTVCVCN QTLCEGLAPT
CSPGHRLLTH FQEDSCCPSY SCECDPDLCE AELVPSCRQD QTLIAGRLGD SCCIFYFCVC
GDCPDPIPEC QEGEALTVDR NTTELCCPLY QCVCESFRCP HIQCVTGTVL VEVWSPDRCC
PYKSCECDCD TIPVPRCHLW EMSQLDEAFM QSEENVCGCT KYECVKAPVC LSRELGVMQL
GQTVVEVSAE GVCHTSRCTT VLDPLTGFYQ INTASVLCDV HCEANQEYEH PRDLAACCGS
CRNVSCLFTF PNGTTSLFLP GASWIADCTR HHCSSTPLGA VLVRSPISCP PLNETECAKA
GGSVVPSLEG CCRTCRRNCV FINFHLCNSR VRWVTPGPVL FDSCGNRVIL LCASIVLGTG
VSIHSGNCGI LMLELKLRAG RGYIQGRQWI RDRLWGWGGQ AACLVPKSSS SLAQSPQAVP
GILPYLTHLP CLVTSTSFQG TELKGRGSNA WALTLVEGPS SMTLTAPVWP TLLPREHYAA
AAASPTLSPQ VKRMDALARR WLSA
//
