ID A0A2Y9M2B9_DELLE Unreviewed; 476 AA.
AC A0A2Y9M2B9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Myocilin {ECO:0000256|ARBA:ARBA00017216};
GN Name=MYOC {ECO:0000313|RefSeq:XP_022415850.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022415850.1};
RN [1] {ECO:0000313|RefSeq:XP_022415850.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022415850.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138}. Cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00004541}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion intermembrane space
CC {ECO:0000256|ARBA:ARBA00004569}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004294}. Rough endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004427}. Secreted, extracellular exosome
CC {ECO:0000256|ARBA:ARBA00004550}. Secreted, extracellular space,
CC extracellular matrix {ECO:0000256|ARBA:ARBA00004498}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00446}.
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DR RefSeq; XP_022415850.1; XM_022560142.1.
DR AlphaFoldDB; A0A2Y9M2B9; -.
DR STRING; 9749.A0A2Y9M2B9; -.
DR KEGG; dle:111167372; -.
DR InParanoid; A0A2Y9M2B9; -.
DR OrthoDB; 2876896at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR23192:SF33; MYOCILIN; 1.
DR PANTHER; PTHR23192; OLFACTOMEDIN-RELATED; 1.
DR Pfam; PF02191; OLF; 1.
DR SMART; SM00284; OLF; 1.
DR PROSITE; PS51132; OLF; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..476
FT /note="Myocilin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016149810"
FT DOMAIN 216..475
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT COILED 107..148
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 476 AA; 53491 MW; 328AAE9E2B09A0FF CRC64;
MPAVQLLLLL LLACLVWGVG ARTAQFRKAN DRSGRCQYTF SVASPNESSC LEQGQAMSAI
QDLQRDSREQ RAALESTKAR LSSLEALLHR LTLGQAAMPW DTQEGLQREL ELAYSHLVRD
KSALEEEKRR LEAENGDLAR RLESSSEEVA SLRRGLCPQF RSTSEDVPPG SKEVSKWNLE
NVDFQELKSE LTEIPASRIL KESPSGQPRS EEGGTGCGEL IWVGEPVTLR TAETLTGKYG
VWMRDPQAAY PYTQETTWRI DTVGTDIRQV FEYDLISQFL QGYPSKVHVL PRPLESTGAV
VYQGSLYFQG AESRTVIRYE LHTETLKAEK EIPGAGYHGQ FPYSWGGYTD IDLAVDETGL
WVIYSTEAAK GAIVLSKLNP ENLELEQTWE TNIRKQSVAN AFVICSTLYT ISSYSLPDAT
VNFAYDTSTG SSKALMVPFK NRYKYSSMID YNPLEKKLFA WDNFNMVTYD IRLSQV
//
