ID A0A2Y9M2U0_DELLE Unreviewed; 71 AA.
AC A0A2Y9M2U0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=General transcription and DNA repair factor IIH subunit TFB5 {ECO:0000256|RuleBase:RU368032};
GN Name=GTF2H5 {ECO:0000313|RefSeq:XP_022416030.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022416030.1};
RN [1] {ECO:0000313|RefSeq:XP_022416030.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022416030.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: In NER, TFIIH acts by opening DNA around the lesion to allow
CC the excision of the damaged oligonucleotide and its replacement by a
CC new DNA fragment. In transcription, TFIIH has an essential role in
CC transcription initiation. When the pre-initiation complex (PIC) has
CC been established, TFIIH is required for promoter opening and promoter
CC escape. {ECO:0000256|RuleBase:RU368032}.
CC -!- SUBUNIT: Component of the 7-subunit TFIIH core complex.
CC {ECO:0000256|RuleBase:RU368032}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU368032}.
CC -!- SIMILARITY: Belongs to the TFB5 family. {ECO:0000256|ARBA:ARBA00007470,
CC ECO:0000256|RuleBase:RU368032}.
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DR RefSeq; XP_022416030.1; XM_022560322.1.
DR AlphaFoldDB; A0A2Y9M2U0; -.
DR STRING; 9749.A0A2Y9M2U0; -.
DR Ensembl; ENSDLET00000019405; ENSDLEP00000017596; ENSDLEG00000012851.
DR KEGG; dle:111167438; -.
DR InParanoid; A0A2Y9M2U0; -.
DR OrthoDB; 419at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071480; P:cellular response to gamma radiation; IEA:Ensembl.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR GO; GO:0006294; P:nucleotide-excision repair, preincision complex assembly; IEA:Ensembl.
DR GO; GO:0006362; P:transcription elongation by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1220; TFB5-like; 1.
DR InterPro; IPR035935; TFB5-like_sf.
DR InterPro; IPR009400; TFIIH_TTDA/Tfb5.
DR PANTHER; PTHR28580; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5; 1.
DR PANTHER; PTHR28580:SF1; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5; 1.
DR Pfam; PF06331; Tfb5; 1.
DR SMART; SM01395; Tbf5; 1.
DR SUPFAM; SSF142897; TFB5-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU368032};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU368032};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368032};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU368032};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU368032}.
SQ SEQUENCE 71 AA; 8067 MW; DBEB4D3C850BC354 CRC64;
MVNVLKGVLI ECDPAMKQFL LYLDESNALG KKFIIQDIDD THIFVIAELV NVLQERVGEL
MDQNAFSLTQ K
//
