ID A0A2Y9M5C9_DELLE Unreviewed; 2168 AA.
AC A0A2Y9M5C9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Unconventional myosin-IXb isoform X4 {ECO:0000313|RefSeq:XP_022414397.1};
GN Name=MYO9B {ECO:0000313|RefSeq:XP_022414397.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022414397.1};
RN [1] {ECO:0000313|RefSeq:XP_022414397.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022414397.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_022414397.1; XM_022558689.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR GO; GO:0030048; P:actin filament-based movement; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd20884; C1_Myosin-IXb; 1.
DR CDD; cd01385; MYSc_Myo9; 1.
DR CDD; cd04407; RhoGAP_myosin_IXB; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 2.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR046987; Myo9.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036023; MYSc_Myo9.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR028557; RhoGAP_myosin_IXB.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46184:SF2; UNCONVENTIONAL MYOSIN-IXB; 1.
DR PANTHER; PTHR46184; UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00109; C1; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 15..118
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 150..988
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1656..1705
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1727..1912
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 870..892
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1081..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1480..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1627..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1944..1971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1991..2168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1372..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2036..2054
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2135..2149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 243..250
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2168 AA; 244700 MW; FB29D705447167EB CRC64;
MSVKEAGSSG HRGQAAYHLH IYPQLATSES QTPCQASCRV TATKDSTTSD VIQDAITSLQ
LDGSKRYVLV EVKETGGEEW VLDANDSPVH RVLLWPRRAQ DEHPQEDGYY FLLQERNADG
TIKYVHMQLV SQATATRRLV ERGLLPRPQA DFDDLCNLPE LTEENLLKNL KHRFLQQKIY
TYAGSILVAV NPFKFLPIYN PKYVKMYENQ QLGKLEPHVF ALADVAYYAM LRKHVNQCIV
ISGESGSGKT QSTNFLIHCL TALSQKGYAS GVERTILGAG PVLEAFGNAK TAHNNNSSRF
GKFIQVNYLE SGIVRGAVVE KYLLEKSRLV SQEKDERNYH VFYYLLLGVS EEERQEFQLK
QPEDYFYLNQ HNLKIEDGED LKHDFERLKQ AMEMVGFLPA TKKQIFSILS AILYLGNVTY
KKKATGRDEG LEVGPPAALD TLSQLLKVKR EILVEVLTKR KTVTSNDKLI LPYSLSEAIT
ARDSMAKSLY SALFDWIVLR INHALLNKKD MEESVSCLSI GVLDIFGFED FERNSFEQFC
INYANEQLQY YFNQHIFKLE QEEYQSEGIS WHNIDYTDNV GCIHLISKKP TGLFYLLDEE
SNFPHATSQT LLAKFKQQHE DNRYFLGTPV MEPAFIIQHF AGKVKYQIKD FREKNMDYMR
PDIVALLRGS DSSYVRELIG MDPVAVFRWA VLRAAIQAMA VLREAGRLRA ERAEKAAAGL
GSSGARGHLG ELQRGASTPS EKLYRCSMLD FSFDGSEEFD INAFEDIIAF YESKNDLHDQ
IIKTIKGLPW QGDDPRRLLQ SLSRLQKPRT FILKSKGIKQ KQIIPKNLLD SKSLKLIISM
TLHDRTTKSL LHLHKKKKPP SISAQFQTSL NKLLEALGKA EPFFIRCIRS NAEKKELCFD
DELVLQQLRY TGMLETVRIR RSGYSAKYTF QDFTEQFQVL LPKNARPCRE VISALLEKMD
IDKRSYQIGK TKVFLKETER QALQETLHRE VVRKILLLQS WFRMVLERRH FLQMRRAAVT
IQACWRSYRV RRALERTQAA VYLQAAWRGS RQRAAYQLQR QTIIRLQSLC RGHLQRRSFS
QMVAEKQKAA EKEREAQRAA KQETAETGPG WAAAQEPSQG PEPSKDGEHL ELEPEVWPSD
GSPVESSQPE KAPPAQKNAA ESHEKVPSSR EKRESRRQRG LEHVKLQNKH IESCKEEHAL
REPSGRAVPG PQESLAEDRK EDREDESPRD ARTDTGMAPP EKQLEEPPQP TPGSLVSTEA
QGGSPRPGHV ERPTSLALDS RVGVPAPGAT PETPKDKSKL GVGPRAQDRP ESPGGSTQIQ
RYRDPDAERL ASAVELWRGK KLMTAGPSTM LSQSLDLSER HRAEGVTLTP TKERRISLST
SDVSKLLSSS SQTKTQPPAE TMDGEPSTKK LAIQKKKSGD ASLGTDAGLS PGSVDSKSTF
KRLFLHKNKD KKYSLEGTEE TENTVPGQVV LEAAAMKKNL EAPSSHQHRH ATGEKHAKEP
GGKGKKNRNL KIGKITVSEK WRESVFRKIT NANELKYLDE FLLNKINDLR SQKTPIESLF
IEATEKFRSN LKTMYSVPNG KIHVGYKDLM ENYQIVVSNL AAERGEKDTN LVLNLFQSLL
DEFTRGHTKN DFEPPKQSKA QKKKRKQERA VQQHNGHVFA SYQVSIPQSC EQCLSYIWLM
DKALLCSVCK MTCHKKCVHK IQTYCSYTSG KKIEPGTEPG HFGVCVDSLT SDKVSVPIVL
EKLLEHVEMH GLYTEGLYRK SGAANRTREL RQALQTDPTA VKLENFPIHA ITGVLKQWLR
ELPEPLMTFA QYGDFLRAVE LPEKQEQLAA IYAVLEHLPE ANHNSLERLI FHLVKVALLE
DVNRMSPSAL AIIFAPCLLR CPDNSDPLTS MKDVLKITTC VEMLIKEQMR KYKVKMEEIT
QLEAAESIAF RRLSLLRQNA IKNPKTRMSS SGGLEELGVL PEEEVAGGEE DREKEILIER
IQSIKEEKED ITYRLPELDP RGSDEENLDS ETSASTESLL EERAGRGASE GPLAPALPCP
SAPTPSPLPE AAAPPRRRPS SFMTVRVKTP RRTPIMPTAN IKLPPGLPSY LPGRAPGAQE
AATPVRRREP PARRPDQVHS VYITPGTHLP TQGPQEPLDK DDRPPGTKRR YSDPPTYCLP
PASGQANG
//
