ID A0A2Y9M684_DELLE Unreviewed; 1655 AA.
AC A0A2Y9M684;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Kinesin-like protein KIF21B isoform X2 {ECO:0000313|RefSeq:XP_022417649.1};
GN Name=KIF21B {ECO:0000313|RefSeq:XP_022417649.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022417649.1};
RN [1] {ECO:0000313|RefSeq:XP_022417649.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022417649.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022417649.1; XM_022561941.1.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01372; KISc_KIF4; 1.
DR CDD; cd22262; Rcc_KIF21B; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR47969; CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED; 1.
DR PANTHER; PTHR47969:SF28; KINESIN-LIKE PROTEIN KIF21B ISOFORM X1; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 67..429
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REPEAT 1336..1375
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1532..1571
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1573..1614
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1615..1645
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 563..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1242..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 437..464
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 681..863
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 971..1040
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 604..633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..668
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 146..153
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1655 AA; 184733 MW; F12A0FE173FEA315 CRC64;
MSCAWWRWAQ AHSRKWRRLD LDPGHPCFQA RAPHPAPRGL VIRLLIRSFW APPCLRFLQP
FPHVMAVTTN AGRIRPQLSK EKIEGCHICT SVTPGEPQVL LGKDKAFTYD FVFDLDTWQE
QIYSTCVSRL VEGCFEGYNA TVLAYGQTGA GKTYTMGTGF DVAMAEEEQG IIPRAIAHLF
GGIAERKRRA QEQGVAGPEF KVSAQFLELY NEEILDLFDS ARDPDARHRR SNIKIHEDAN
GGIYTTGVTS RLISSQEELI QCLKQGALSR TTASTQMNVQ SSRSHAIFTI HVCQMRLCTR
PDLVNEAVTG LPDGTAPSGE YETLTAKFHF VDLAGSERLK RTGATGERAK EGISINCGLL
ALGNVISALG DQSKKVVHVP YRDSKLTRLL QDSLGGNSQT IMIACVSPSD RDFMETLNTL
KYANRARNIK NKVVVNQDKT SQQISALRAE IARLQMELME YKAGKRVIGE DGAEGYSDLF
RENAMLQKEN GALRLRVKAM QEAIDAINSR VTQLMSQEAN LLLAKAGDGS EAIGALIQNY
IREIEDLRTK LLESEAMNES LRRSLSRAST RGPYSLGASP VVPTGSMEDA AEVIRRAKQD
LERLKKKEVR QRRKSPEKEA FKKRAKLQQE NSEETDDNEA EEEDEEPEES GREDEDSGSE
ESLVDSDSDP EDKEVNYQAD LADLTCEIEI KQKLIDELEN SQRRLQTLKH QYEEKLILLQ
NKIRDTQLER DRVLQNLSTM ECYTEEKANK IKADYEKRLR EMNRDLQKLQ AAQKEHARLL
KNQSRYEREL KKLQAEVAEM KKAKVALMKQ MREEQHRRRL AETKRNREIA QLKKEQRRQE
FQIRALESQK RQQEMVLRRK TQEVSALRRL AKPMSERVAG RVGPKSPMLD SGAEVSASTT
SSEAESGARS VSSIVRQWDH KISHFLENHP MPTVSGARPA RKKFQKKGAS QSFSKAARLK
WQSLERRIVD IVMQRMAIAN LEADMERLIK KREELSLLQE ALRRKRERLQ AESPEEEKGL
QELAEEIEVL AANIDYINDS IGDCQATIVQ LEETKEELDS TDTSVVISSC SLAEARLLLD
NFLKASIDKG LQVAQKEAQI RLLEGRLRQT DIAGPSQNHL LLDALREKAE AHPELQALIH
NVQQENGYAS TDEEVSEFSE GSFSQSFTMK GSTSHDDFKF KGEPKLSAQM KAVSAECLGP
PLDVSTKNIT KSLASLVEIK EDGVGFSIRD PYYRDKVSRT ISLPSRGSTF PRQSRGAETS
PLTRRKSYDR GQPIRSTDVG FTPPSSPPTR PRNDRNVFSR LTSNQSQGSA LDKGIITPVG
GARGARTAPL QCVSMAEGHT KPILCLDATD ELLFTGSKDR SCKMWNLVTG QEIAALKGHP
SNVVSIKYCS LSGLVFSVST SYIKVWDIRD SAKCVRTLTS SGQVVSGDAC AAASTRTITS
AQGEHQINQI ALSPSGSMLY AASGNAVRIW ELNRFQPVGK LTGHIGPVMC LTVAQTASQH
DLVVTGSKDH YVKMFQLGEC VTGTVGPTHN FEPPHYDGIE CLAIQGDVLF SGSRDNGIKK
WDLAQQELMQ QIPTAHKDWV CALAFVPGRP MLLSACRAGV IKVWNVDNFT PIGEIKGHDS
PINAMCTNAR HIFSASSDLT VKFWSARRLV PSGPH
//
