ID A0A2Y9M718_DELLE Unreviewed; 1117 AA.
AC A0A2Y9M718;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Unconventional myosin-If isoform X1 {ECO:0000313|RefSeq:XP_022413153.1};
GN Name=MYO1F {ECO:0000313|RefSeq:XP_022413153.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022413153.1};
RN [1] {ECO:0000313|RefSeq:XP_022413153.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022413153.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_022413153.1; XM_022557445.1.
DR AlphaFoldDB; A0A2Y9M718; -.
DR STRING; 9749.A0A2Y9M718; -.
DR Ensembl; ENSDLET00000020530; ENSDLEP00000018623; ENSDLEG00000012681.
DR KEGG; dle:111166117; -.
DR InParanoid; A0A2Y9M718; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01378; MYSc_Myo1; 1.
DR CDD; cd11827; SH3_MyoIe_If_like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035507; Ie/If_SH3.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF663; UNCONVENTIONAL MYOSIN-IF; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 36..709
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 747..936
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT DOMAIN 1060..1117
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 586..608
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 928..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 129..136
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1117 AA; 127543 MW; 8951ACDFFF937BD5 CRC64;
MQKKEGRRWG RGQRQKLLME GSKERFHWQS HNVKQSGVDD MVLLPQITED AIVGNLRKRF
MDDYIFTYIG SVLISVNPFK QMPYFTDREI DLYQGAAQYE NPPHIYALTD NMYRNMLIDC
ENQCVIISGE SGAGKTVAAK YIMGYISKVS GGGEKVQHVK DIILQSNPLL EAFGNAKTVR
NNNSSRFGKY FEIQFSRGGE PDGGKISNFL LEKSRVVMQN ENERNFHIYY QLLEGASQEQ
RQNLGLMTPD YYYYLNQADT YKVDGTDDRS DFSETLSAMQ VIGIPPNVQQ LVLQLVAGIL
HLGNISFCED GNYARVESAD LLAFPAYLLG IDSGRLQEKL TSRKMDSRWG GRSESIDVTL
NVEQAAYTRD ALAKGLYSRL FDFLVEAINR AMQKPQEEYS IGVLDIYGFE IFQKNGFEQF
CINFVNEKLQ QIFIELTLKA EQEEYVQEGI RWTPIQYFNN KIVCDLIENK LNPPGIMSVL
DDVCATMHAT GGGADQTLLQ KLQAAVGTHE HFNSWSAGFV IHHYAGKVSY DVNGFCERNR
DVLFSDLIEL MQTSEQAFLR MLFPEKLDVE KKGRPSTAGS KIKKQANDLV STLKRCTPHY
IRCIKPNETK RPRDWEENRV KHQVEYLGLK ENIRVRRAGF AYRRQFAKFL QRYAILTPET
WPHWRGDERQ GVQHLLWAVN MEPDQYQMGS TKVFVKNPES LFLLEEMRER KFDGFARTIQ
KAWRRHVAVR KYEEMREEAS NILLNKKERR RNSINRNFVG DYLGLEERPE LRQFLGKRER
VDFADSVNKY DRRFKAIKRD LILTPKCVYV IGREKVKKGP EKGQVREVLK KKLEIQALRG
VSLSTRQDDF FILQEDAADS FLESVFKTEF VSLLCKRFEE AVRRPLPLTF SDTLQFRVKK
EGWGGGGTRS VTFSRGSGDV AMLKASSRTL SVSVGDGLPK SSKPTRKGMA QGKPRRSAQA
PTRAAPGPPR GLDRNGVPPS ARGGPLPLEF TSRRGSQKPP QGPPSSALGA SRRQRARPPS
EHNTEFLNVP DQGMAGMQRK RSIGQRPVPG VGRPKPQPRT HGPRCRALYQ YVGQDVDELS
FNVNEVIEIL MEDSSGWWKG RLHGQEGLFP GNYVEKI
//
