ID A0A2Y9M880_DELLE Unreviewed; 1169 AA.
AC A0A2Y9M880;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho GTPase-activating protein 20 isoform X2 {ECO:0000313|RefSeq:XP_022417271.1};
GN Name=ARHGAP20 {ECO:0000313|RefSeq:XP_022417271.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022417271.1};
RN [1] {ECO:0000313|RefSeq:XP_022417271.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022417271.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022417271.1; XM_022561563.1.
DR AlphaFoldDB; A0A2Y9M880; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13319; PH_RARhoGAP; 1.
DR CDD; cd17115; RA_RHG20; 1.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR047887; ARHGAP20_PH.
DR InterPro; IPR047888; ARHGAP20_RA.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23179:SF28; RHO GTPASE-ACTIVATING PROTEIN 20; 1.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 173..262
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 344..530
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1045
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1169 AA; 130345 MW; 91668DD98FC2DE79 CRC64;
MEAMSPQQET LGGQPARSSS LTGVSRIAGA PGTKKKMKTL AERRRSAPSL ILDKALQKRP
STKTLLIDGR VELKRGLQRQ ERHLFLFNDL FIVAKIKYNN NFKIKNKIKL SDMWTASCVD
EVGEGNTNAL KSFVLGWPTV NFVATFSSPE QKDRWLSLLQ RYINLEKEKD YPKSIPLKIF
AKDIGNCAYS KTITVTNSDT ANEVINMSLP MLGITGSERE YQLWVNSGKE EAPYPLIGHE
YPYGIKMSHL RDTTLLTQGS KDSPTPSNFQ EPFLMEQLPR EMQCQFILKP SRLAVAQQLS
DSGQKTFKRR RSIINWAFWR GSSTHLDNLP MSPTSPVPGQ LFGVSLPNIC ENDNLPKAVL
DMLFFLNQKG PLTKGIFRQS ANVKSCRELK EKLNSGAEVQ LDCESIFVIA SVLKDFLRNI
PGSTFSSDLY DHWVCVMDQG NDEEKIHAVQ RLLDQLPRAN VILLRYLFGV LYNIEQHSSS
NQMTAFNLAV CIAPSILWPP TSSSPELENE FTKKVSLLIQ FLIENCCRIF GEEITSLLGE
VSVRCDTREN ASDISCFQLN DSSYDSLENE LNEDVDAPCS DLVKKLGQGS RSMDSVLTLS
DYDLDQPEVE GLLTLSDFDL DHSKDEDIQM EQPLESKPVN IAVYTKEPLQ DHARAPSGMS
TPSHLSTTAA DAPKSLRRHR RCSEPSYDYL DSKLSYLREF YQKKLRKSSC DAVLSKKDES
HLNQNQPLQE EGKTCFKKSL VIGTDIKKNA TNKNVKKKSL SDNEGNHVKL FPKSKPVAIS
MASYSHMSSC DHPRNQTFDT DRSGYSPPHT TDTLKSSRRH RRCSEPNIDD QHCKLTYLRG
IHSKKQHKAS YEASLLHGEE DYLKRHKSLQ MEGQKLINQS LVMGIEVGKT SATNQNTDKV
LPPRLNICSR TSYSSLSSPG TSPSGSSVSS QDSAFSQISE HSVFTPTETS SPIDCTFQAQ
RKQEELSSDF SSSSLISGIP GPSSGQASGH LAYTKKDSVE WHSQMHSVTL HPSTWLRNGV
ASLKNWSLKK KARAPRPEEN KIGSLKGHTE PPPHASGVPE ANALHERQKD MPRRAAEGLG
AVQTARWYSS YPSQDSEKHC SSPVSLVEDR LGLCMKSPEE GEISGQCSPG TLPHGRSSPS
SLTVDHVCSP DSGPTVVCDV EDRHLTKDI
//
