ID A0A2Y9M8I4_DELLE Unreviewed; 1226 AA.
AC A0A2Y9M8I4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=AF4/FMR2 family member 1 isoform X4 {ECO:0000313|RefSeq:XP_022417371.1};
GN Name=AFF1 {ECO:0000313|RefSeq:XP_022417371.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022417371.1};
RN [1] {ECO:0000313|RefSeq:XP_022417371.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022417371.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; XP_022417371.1; XM_022561663.1.
DR AlphaFoldDB; A0A2Y9M8I4; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF6; AF4_FMR2 FAMILY MEMBER 1; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 963..1225
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 26..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..297
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..938
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1226 AA; 132863 MW; AF771212638198B3 CRC64;
MAFTERVNSS GNSLYNEDRN LLRIREKERR NQEAHQEKEA FSEKIPLFGE PYKTEKGDEL
SSRIQNMLGN YEEVKEFLST KSHPQRLDAS ENRLGKPRYP SFPEKGSSIP SHSFHTSVHH
QPINTPASGP LPIGTISHNP KMAQPRMEPM PSLHVKSYGP PDTQHMTQDR LGQEGYSSSH
HKKGDRRADG DHCASMTDSA PERELSPLFS LPSPVPPLSP VHSNQQTLPR MQGSNKVHSS
NSNNKGYCPA KSPKDLLVKV HDKETLQDSS VAVASLGVAP PQPPSQTFPP PPLPSKSLAM
QQKPTAYVRP MDGQDQAPSE SPELKPLPED YRQQSFEKTD LKVPAKAKLT KLKMPSQSVE
TYSSEVHCVE EILKEMTHSW PPPLTAIHTP STAEPSKFPF PAKDSQHISS ATLNQKQYDA
SSKTHSNSQQ GTSMLKDDLQ LSDSEDSDSD QTPEKPPSAS APPSAPQALP AAAASAHSSS
AESESTSDSD SSSDSESESS SSDSEENEPR EAPAPEPEPP TTNKWQLDNW LTKVSQPAPP
AEAPGSAVPP ARHPDSKGKG GDGATGGHER SESKEPPLKS SSKAPRVPSE GPHAGKRSCQ
KSPAQQEPPQ RQTVGSKQPK KPVKASAPGH ADAHADARTS LLVESEPGLP PQASKDQPSK
DKPKVKTKGR PRAAESREPK PVAPTPSERK KHRSGPPAPP KAPPKDAAED RSPEHFALVP
LTQSQGPARS GGARTSGCRL AVVVQEDRRK DKPLVPLRDT KLLSPLRDTP LPQSLMVKIT
LDLLSRIPQP AGKGSRPKKP EDKQPSAAKK ADSEKRSSEN SSKLAKKRKG EAERDHDSKK
IRLEKEVKSQ SSPSSSHKES SKSKAPRPSS EPSKKEMLPP SLVSSSSSQK PAKPAQKRSR
QEADPSGQDP PKSASSTKGN HRDSSVSKHR KVEGKGPGSS TEHKGSSGDT ANRFPVPSLP
NGNSKPGKPH MKLDKQQADF HMKEARRLKD KAELVTDKVG KAFKYLEAAL SFIECGIAME
LESPASKSAC SIYAETLDLI KFIMSLKSFS DATTPTQEKI FAVLCMRCQS ILNMAMFRCK
KDIAIKYSRT LNEHFFKTSS KVAQAPSPCI ARSTGTPSPL SPMPSPASSI GSQSSAGSVG
SGGMPATIST PVTIQSMTSS YVTITSHVLT AFDLWEQAEV LTRKNKEFFA QLSTGVCTLA
LDSSLMDLVR YTRQGFQRLK QVTKTP
//
