ID A0A2Y9MAP3_DELLE Unreviewed; 349 AA.
AC A0A2Y9MAP3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=choline-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00026101};
DE EC=2.7.7.15 {ECO:0000256|ARBA:ARBA00026101};
GN Name=PCYT1B {ECO:0000313|RefSeq:XP_022416172.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022416172.1};
RN [1] {ECO:0000313|RefSeq:XP_022416172.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022416172.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the key rate-limiting step in the CDP-choline
CC pathway for phosphatidylcholine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00025501}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CTP + H(+) + phosphocholine = CDP-choline + diphosphate;
CC Xref=Rhea:RHEA:18997, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:58779, ChEBI:CHEBI:295975;
CC EC=2.7.7.15; Evidence={ECO:0000256|ARBA:ARBA00024554};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18998;
CC Evidence={ECO:0000256|ARBA:ARBA00024554};
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis;
CC phosphatidylcholine from phosphocholine: step 1/2.
CC {ECO:0000256|ARBA:ARBA00025706}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR RefSeq; XP_022416172.1; XM_022560464.2.
DR AlphaFoldDB; A0A2Y9MAP3; -.
DR Ensembl; ENSDLET00000005544; ENSDLEP00000004987; ENSDLEG00000003770.
DR UniPathway; UPA00753; UER00739.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0004105; F:choline-phosphate cytidylyltransferase activity; IEA:InterPro.
DR CDD; cd02174; CCT; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR045049; Pcy1-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR10739:SF20; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE B; 1.
DR PANTHER; PTHR10739; CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotidyltransferase {ECO:0000313|RefSeq:XP_022416172.1};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transferase {ECO:0000313|RefSeq:XP_022416172.1}.
FT DOMAIN 60..188
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 289..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 219..246
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 289..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 349 AA; 39788 MW; 744F031F0450255F CRC64;
MSATLLTMAF LPAEYPRVWT LTAPAPFADE SSCQCQAPHE KLTIAQARLG TPVDRPVRVY
ADGIFDLFHS GHARALMQAK TLFPNSYLLV GVCSDDLTHK FKGFTVMNEA ERYEALRHCR
YVDEVIRDAP WTLTPEFLEK HKIDFVAHDD IPYSSAGSDD VYKHIKEAGM FVPTQRTEGI
STSDIITRIV RDYDVYARRN LQRGYTAKEL NVSFINEKKY RFQNQVDKMK EKVKNVEEKS
KEFVNRVEEK SHDLIQKWEE KSREFIGNFL ELFGPDGAWK QMFQERSSRM LQALSPKQSP
VSSPTRSRSP SRSPSPTFSW LPNKTSPPSS PKAASASISS MSEGDEDEK
//
