ID A0A2Y9MC03_DELLE Unreviewed; 1174 AA.
AC A0A2Y9MC03;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Double-stranded RNA-specific adenosine deaminase isoform X1 {ECO:0000313|RefSeq:XP_022414943.1};
GN Name=ADAR {ECO:0000313|RefSeq:XP_022414943.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022414943.1};
RN [1] {ECO:0000313|RefSeq:XP_022414943.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022414943.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022414943.1; XM_022559235.2.
DR AlphaFoldDB; A0A2Y9MC03; -.
DR STRING; 9749.A0A2Y9MC03; -.
DR KEGG; dle:111166955; -.
DR InParanoid; A0A2Y9MC03; -.
DR OrthoDB; 118472at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19913; DSRM_DRADA_rpt1; 1.
DR CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044456; ADAR1_DSRM_1.
DR InterPro; IPR044457; ADAR1_DSRM_3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF02295; z-alpha; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00550; Zalpha; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 3.
DR PROSITE; PS50139; Z_BINDING; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 130..196
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 241..305
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 451..519
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 562..630
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 674..742
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 834..1169
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 203..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 130512 MW; 4C014B39F779697D CRC64;
MDPRQGCSLN RYQTHPVQGY EHSKLRHQQP GLGSYPNSFR LQQIEFLKGQ LPEAPLIGKQ
APSLPLFLPG LGPRFPGPPA RGGYLQIPGV LRGVPLRSQV LPGGFQHPTP RGWVQPWRGV
DTLSSRFREL TISQDQEQRI LELLEELGER KATTALDLAR KLQAQKKEIN RVLYSLAKKG
KLHREAGTPP LWRLSVPVQA WNQPSQVARA DSHSQGAPSS DFSLETEDRS LTSGLEDPPE
PLDMAEIKEK ICDYLFNVSN SSALNLAKNI GFTRARDVTA VLIDLERQGD VYRQGTTPPI
WHLTDKKRER IQIKRNTNNV PETTQAAIQE TRKIAELPTC NLPASDASNS MDTTEKVENG
QEPVVKLETR QEVTPEPIKL KPPVHDNGPS KTGYVDFENG QWATDDIPDD LNSIHAAPGE
FRAIMEMPSF YSHGLPRCSP YKKLTECQLK NPISGLLEYA QFASQTCEFN LIEQSGPPHE
PRFKFQVVIS GREFPPAEAG SKKVAKQDAA MKAMTILLEE AKAKDSGRSE ESYYCSSEKE
SEKTAESQTT TPSATSFLSG KNPVTTLLEC VHKLGSSCEF RLLSREGPAH DPKFQYCVAM
GTHTFPTASA PSKKAAKQMA AEEAMKALQG EATGSTSSDD QPGSMNTESF DNLESVMPSK
VRRISELVRY LNTNPVGGLL EYARSHGFAA EFKLVDQSGP PHEPKFVYQA KVGGRWFPAV
CAHSKKQGKQ EAADAALRVL IGEDEKAERM GFTEVTPVTG ASLRRTMLLL SRSPEAQPKT
LPLTGSTFHD QIAMLSHRCF NALTNSFQPS LLGRKILAAI IMKKDSEDLG VVVSLGTGNR
CVKGDSLSLK GETVNDCHAE IISRRGFIRF LYSELMKYNP QTAKDSIFEP AKGGEKLQIK
KTVSFHLYIS TAPCGDGALF DKSCSDRAVE STDSRHYPVF ENPKQGKLRT KVENGEGTIP
VESSDIVPTW DGIRLGERLR TMSCSDKILR WNVLGLQGAL LTHFLQPVYL KSVTLGYLFS
QGHLTRAICC RVTRDGSAFE DGLRHPFIVN HPKVGRVSVY DSKRQSGKTK ETSVNWCLAD
GYDLEILDGT RGTVDGPRNE LSRVSKKNIF LLFKKLCSFR YRRDLLRLSY GEAKKAARDY
EIAKNYFKKS LKDMGYGNWI SKPQEEKNFY LCPV
//
