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Database: UniProt
Entry: A0A2Y9MDD0_DELLE
LinkDB: A0A2Y9MDD0_DELLE
Original site: A0A2Y9MDD0_DELLE 
ID   A0A2Y9MDD0_DELLE        Unreviewed;       364 AA.
AC   A0A2Y9MDD0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Tumor necrosis factor receptor superfamily member 27 {ECO:0000313|RefSeq:XP_022419790.1};
GN   Name=EDA2R {ECO:0000313|RefSeq:XP_022419790.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022419790.1};
RN   [1] {ECO:0000313|RefSeq:XP_022419790.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022419790.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   RefSeq; XP_022419790.1; XM_022564082.1.
DR   AlphaFoldDB; A0A2Y9MDD0; -.
DR   STRING; 9749.A0A2Y9MDD0; -.
DR   KEGG; dle:111169703; -.
DR   InParanoid; A0A2Y9MDD0; -.
DR   OrthoDB; 5405444at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR   CDD; cd15838; TNFRSF27; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR022319; TNFR_27.
DR   InterPro; IPR034060; TNFRSF27_N.
DR   InterPro; IPR047526; TNR19/27/EDAR.
DR   PANTHER; PTHR12120; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12120:SF8; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 27; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PRINTS; PR01973; TNFACTORR27.
DR   SMART; SM00208; TNFR; 2.
DR   SUPFAM; SSF57586; TNF receptor-like; 1.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170,
KW   ECO:0000313|RefSeq:XP_022419790.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        139..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..41
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REPEAT          2..41
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DOMAIN          43..83
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REPEAT          43..83
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   REGION          246..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        18..31
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   364 AA;  40280 MW;  0F82AF504FA86E4F CRC64;
     MDCQENEYWD QWGRCVACQL CGPGQELSKD CGYGEGGDAY CAACPPRRYK SSWGHHRCQT
     CITCAVINRI QKENCTATSN AVCGDCLPRF YQKTRIGGLQ DQECIPCTKQ TPTSEVQCAF
     QLSLVKADVP TVSPQEVTLV ALVSSLLMVF TLAFLGLFFL YCKQFFNRNC QRGWIILSLT
     LEASFSDKSC CPVPGHGHET WEMKHLGPRA RKEEDEATSE SCLSPSSCLR RREMVSGGSL
     QYEADEAAEE ESLFPMPPGQ ETSPESPLSE SIFETQALNP ILDDDCSSTR GFPTQESFTL
     ASCASESHSH WVHTPIECTE LDLRKISSSA SYTGAETLRG NTAERSGDRL ELTVPFEVPS
     LSLY
//
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