ID A0A2Y9ME88_DELLE Unreviewed; 3509 AA.
AC A0A2Y9ME88;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=WD repeat and FYVE domain-containing protein 3 isoform X3 {ECO:0000313|RefSeq:XP_022417352.2};
GN Name=WDFY3 {ECO:0000313|RefSeq:XP_022417352.2};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022417352.2};
RN [1] {ECO:0000313|RefSeq:XP_022417352.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022417352.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022417352.2; XM_022561644.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF1; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2514..2639
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2666..2959
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3106..3147
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3437..3497
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 2442..2505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3257..3318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2447..2461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3257..3272
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3273..3311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3509 AA; 393620 MW; 29C8641F17002CB5 CRC64;
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR
VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEINQSEEA
SRGWMLLTTI NLLASSGQKT VDCMTTMSVP STLVKCLYLF FDLPHVPEAV GGAQNELPLA
ERRGLLQKVF VQILVKLCSF VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM
TISRHGLSVN VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL
LDDFRIWQGY SFLCDLLLRL EQAKEAESKD ALKDLVNLIT SLTTYGVSEL KPAGITTGAP
FLLPGFAVPQ PAGKGHSVRN IQAFAVLQNA FLKAKTNFLA HIILDAITNI YMADNANYFI
LESQHTLSQF AEKISKLPEV QNKYFEMLEF VVFSLNYIPC KELISVSILL KSSSSYHCSI
IAMKTLLKFT RHDYIFKDVF REVGLLEVMV NLLHKYAALL KDPTQALHEQ GDSRNNSSFE
DQKHLALLVM ETLTVLLQGS NTNAGIFREF GGARCAHNIV RYPQCRQHAL MMIQQLVLSP
NGDDDMGTLL GLMHSAPPTE LQLKTDILRA LLSVLRESHR SRTVFRKVGG FVYITSLLVA
MERSLSSPPK NGWEKVNQNQ VFELLHTVFC TLTAAMRYEP ANSHFFKTEI QYEKLADAVR
FLGCFSDLRK ISPMNVFPSN TQPFQRLLEE DVILMDSVSP TLRHCSKLFI YLYKVATDSF
DSRAEQIPPC LTSESSLPSP WGTPALSRKR HAYHSVSTPP VYPTKNVADL KLHVATSSLQ
SSDAVIIHPG AMLSMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL
HARLLQRCSA ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL NCGAWDKKLL
KQYRVHKPSS LSYEPEMRSS MITSMEGLCS DSVFSLHEDN HYRISKSLVK SAEGSTVPLT
RVKCLVSMTT PHDIRLHGSS VTPTFVEFDT SLEGFGCLFL PSLAPHNAPT NNAVTTGLTD
GAVVSGIGSG ERFFPPPSGL SYSSWFCIEH FSSPPNNHPV RLLTIVRRAN SSEQHYVCLA
IVLSAKDRSL IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELIIE GQWHHLVLVM
SRGMLKNSTA ALYIDGQLVS TVKLHYVHST PGGSGSANPP VVSTVYAYIG TPPAQRQIAS
LVWRLGPTHF LEEVLPPSNV TTIFELGPNY VGSFQAVCMP CKDAKSEGVV PSPVSLVPEE
KVSFGLYALS VSALTVARIR KVYNKLDSKA IAKQLGISSH ENATPVKLIH NSAGHLNGPA
RTVGATLIGY LGVRTFVPKP VATTLQYIGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS
NPLASKEMER IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD
LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL LTLRDMSLSQ
PTIAAISNVL SFLLQGFPNS NDLLRFGQFI SSTLPTFAVC EKFVVMEINH EEKPDTGTEE
EFGGLVSANL ILLRNRLLDI LLKLVYTSKE KTSINLQACE ELVRTLGFDW IMMFMEEHLH
STTVTAAMRI LVVLLSNQSI LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR
STVREINRDA CHFPGFPVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVIS
SRCKQGCQFD LDSIWTFIFG VPASSGTVVS SIHNVCTEAA FLLLGMLRSM LNSPWQSEEE
GSWLREYPVT LMQFFRYLYH NVPDLASMWM SPDFLCALAA TVFPFNIRPY SEMVTDLDDE
VGSPAEEFKA FAADTGMNRS QSEYCNVGVK TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS
KQTPLIDLLL EASPERSTRT QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITSGGSYQV
LVNNVFYFTQ RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL
YQFSRAHKTV PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN LHVGSNVDGF
GLEAEARMTT WHIMIPSDIE PDGGYSQDIS EGRQLLIKAV NRVWTELIHS KKQTLEELFK
VTLPVNERGH VDIAIAKPLI EEAGLKCWQN HLAHEKKCIS RGEALVPTTQ SKLSRVSSGF
GLSKLTGSRR NRKESGLHKH SLSTQEISQW MFTHIAVVRD LVDTQYKEYQ ERQQNALKYV
TEEWCQIEYE LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YTHYPYVPET
EQETNVAKPA RYRRAVSYDS KEYYMRLASG NPAIVQDAIV ESSEGEATQQ EPEHGEDTIA
KVKGLVKPPL KRSRSAPDGG DEETQEQLQD QIAEGSSIEE EEKTDNATLL RLLEEGEKIQ
HMYRCARVQG LDTSEGLLLF GKEHFYVIDG FTMTATREIR DIETLPPNMH EPIIPRGARQ
GPSQLKRTCS IFAYEDIKEV HKRRYLLQPI AVEVFSGDGR NYLLAFQKGI RNKVYQRFLA
VVPSLTDSSE SVSGQRPNTS VEQGSGLLST LVGEKSVTQR WERGEISNFQ YLMHLNTLAG
RSYNDLMQYP VFPWILADYD SEEVDLTNPK TFRNLAKPMG AQTDERLAQY KKRYKDWEDP
NGETPAYHYG THYSSAMIVA SYLVRMEPFT QIFLRLQGGH FDLADRMFHS VREAWYSASK
HNMADVKELI PEFFYLPEFL FNSNNFDLGC KQNGTKLGDV ILPPWAKGDP REFIRVHREA
LECDYVSAHL HEWIDLIFGY KQQGPAAVEA VNVFHHLFYE GQVDIYNIND PLKETATIGF
INNFGQIPKQ LFKKPHPPKR VRSRLNGDNA GILVPPGSTS DKIFFHHLDN LRPSLTPVKE
LKEPVGQIVC TDKGILAVEQ NKVLIPPTWN KTFAWGYADL SCRLGTYESD KVVTVYECLS
EWAQILCAIC PNPKLVITGG TSTVVCVWEM GASKEKAKTL TLKQALLGHT DTVTCATASL
AYHIIVSGSR DRTCIIWDLN KLSFLTQLRG HRAPVSALCI NELTGDIVSC AGTYIHVWSI
NGNPVVSVNT FTGRSQQIIC CCVSEMNEWD TQNVIVTGHS DGVVRFWRME FLQVPETPAP
ETVEVLEMQE DCPEAQIGPE AQEEDSSDSE ADEQSIIQDP GDTPSQPSST SHRPRAASCR
ATATWCNDSG SDDSRRWSDQ LSLDEKDGFV FVNYSEGQTR PHLQAPLNHP HPNPAEARNF
SRLKPGYRWE RQLVFRSKLT MHTAFDRKDN AHPAEITALG VSKDHSRILV GDSRGRVFSW
SVSDQPGRSA ADHWVKDEGG DSCSGCSVRF SLTERRHHCR NCGQLFCQKC SRFQSEIKRL
KISSPVRVCQ NCYYNLQHER GSEDGPRNC
//
