ID A0A2Y9MEW9_DELLE Unreviewed; 961 AA.
AC A0A2Y9MEW9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A1 {ECO:0000313|RefSeq:XP_022420809.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022420809.1};
RN [1] {ECO:0000313|RefSeq:XP_022420809.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022420809.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) +
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00034408};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR RefSeq; XP_022420809.1; XM_022565101.2.
DR AlphaFoldDB; A0A2Y9MEW9; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR002977; Anion_exchange_1.
DR InterPro; IPR018241; Anion_exchange_CS.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF12; BAND 3 ANION TRANSPORT PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 2.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01187; ANIONEXHNGR1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR PROSITE; PS00219; ANION_EXCHANGER_1; 1.
DR PROSITE; PS00220; ANION_EXCHANGER_2; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 454..477
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 498..520
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 540..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 572..594
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 614..633
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 708..729
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 750..773
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 810..829
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 836..860
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 880..899
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 906..928
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 127..374
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 426..606
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT DOMAIN 615..887
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
SQ SEQUENCE 961 AA; 106968 MW; AB2ABCCD146CC895 CRC64;
MFLELVIPGD GQKRKPGTCS VGYAGGSDHC RQLNNQDSAM GDSQENEDKL EEFLEQKEYE
DLGFPTLQVE EAEAQLTEPT ATDYHTASRR PPDVLEVVVE LRELVMDEKN QELQWMETAR
WVQLEENLGK GGIWGRPHLS YLTFWSLLEL QKAFAKGTVL LDLPEKSLAG VASQLLDRFI
FEGQIQPQDR ENLFRVLLLK HSHARDVEAL GSVKPAVLTR SGDPSQPLLP QHPSLETEVF
CEQGEGSAEG HSSSGMLGKS PQDREATLVL VGCARFLERP VLGFVRLKEP METEQKPQEP
EGPAVPVRFL IVLLGPEAPN IDYTQLGRAA ATLMSERVFR TDAYLAQNKE MLVHSLEGFL
DCSLVLPPTD APPEDALLSL VPVQKELLKR RYLPSSAKPE PSFLKGLDLN GGLEDTQDDP
LQRTGRLFGG LVRDIRRRYP RYLSDITDAL NPQVLSAIIF IYFAALSPAI TFGGLLGEKT
HNLMGVSELL ISTAAQGILF SLLGAQPLLV VGFSGPLLVF EEAFFSFCKS NGLEYIVGRV
WIGFWLILLV VLVVAFEGSF LVRFISRYTQ EIFSFLISLI FIYETFSKLV TIFQDHPLLE
NYDHNVTRIP KPQAPLPNTA LLSLVLMAGT FLFAMMLRKF KNSSYFPGKL RRVIGDFGVP
ISILIMVMVD ALIQDTYTQK LSVPKGLTVS NTSARGWLIH PLGLYKPFPI WMMFASALPA
LLVFILIFLE SQITTLIISK PERKVAKGSG FHLDLLLVMG MGGVATLFGM PWLSATTVRS
VTHANALTVT GKASTPGTAA QIQEVKEQRI SGLLVSVLVG LSILMGPILS HIPLAVLFGI
FLYMGVTSLS GIQLFDRILL LFKPRKYHPD VPYAKRVRTW RMHLFTGTQI ICLVVLWVVR
SIKTISLALP FILILTVPLR HFLLPLIFQN LELQCLDADN AKPNFDEENG QDEYDEVAMP
V
//
