ID A0A2Y9MFC3_DELLE Unreviewed; 623 AA.
AC A0A2Y9MFC3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Neurotrophin receptor-interacting factor homolog isoform X5 {ECO:0000313|RefSeq:XP_022420540.1};
GN Name=ZNF274 {ECO:0000313|RefSeq:XP_022420540.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022420540.1};
RN [1] {ECO:0000313|RefSeq:XP_022420540.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022420540.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
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DR RefSeq; XP_022420540.1; XM_022564832.2.
DR AlphaFoldDB; A0A2Y9MFC3; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 2.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 6.10.140.140; -; 2.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF90; KRAB DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01352; KRAB; 2.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 2.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 2.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50805; KRAB; 2.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Receptor {ECO:0000313|RefSeq:XP_022420540.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 161..239
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 280..357
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 477..504
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 505..532
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 533..560
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 561..588
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 589..616
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 384..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 70728 MW; 6D41CF1DBFC3A04D CRC64;
MATGLPTAWF REPVTFEDVT LGFTPDEWGM LDLEQKSLYR EVLLENYRNL VSVEHQLSKP
DVVSQLEEEE ELWSVERGIP RDTFSECPEA QLDPQFHPFP AGNPLMKIEV VEILTLNEEV
ALPRNAQIRA LYAEDEGLSP DILREPTQHL DKHPTDPETA RQRFRGFRFE EVAGPREALA
RLRELCRQWL RPEVHSREQM LELLVLEQFL GALPGKLRMW VESQHPVDCQ EAVVLVEDVT
WISEEEALPT QGPTSSLQTT AQQEEDMATR LVKALPEEPV TFLDVAVDFS REEWGLLDLT
QRTEYHDVML ETFGHLVSVG WETTLESKQL TPNPNTPVEE PACHLKVEEF SRDDTQPSTS
GDTLQAGAPE VLDTALKPVV LTQEKTLPQK PPGESPKPQA STGPDTSHIS LQKTIPRKRL
RKRDPTVKKM THNPCVKLHQ KSCSRGKDQE SGSCGRTLSR STQQITFTRI HKGSQVCRCS
ECGKTFRNPR YFSVHKKIHT GEKPYVCPDC GKAFVQSSSL TQHQRVHTGE RPFECHECGR
TFNDRSAISQ HLRTHTGAKP YPCQDCGKAF RQSSHLIRHQ RTHTGERPYT CNKCGKAFTQ
SSHLIGHQKT HSGVKCKKKQ PTS
//