ID A0A2Y9MGM4_DELLE Unreviewed; 479 AA.
AC A0A2Y9MGM4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Single Ig IL-1-related receptor isoform X1 {ECO:0000313|RefSeq:XP_022421070.1};
GN Name=SIGIRR {ECO:0000313|RefSeq:XP_022421070.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022421070.1};
RN [1] {ECO:0000313|RefSeq:XP_022421070.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022421070.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR RefSeq; XP_022421070.1; XM_022565362.2.
DR AlphaFoldDB; A0A2Y9MGM4; -.
DR STRING; 9749.A0A2Y9MGM4; -.
DR KEGG; dle:111170315; -.
DR InParanoid; A0A2Y9MGM4; -.
DR OrthoDB; 5349166at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF19; SINGLE IG IL-1-RELATED RECEPTOR; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_022421070.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 184..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..178
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 232..376
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 479 AA; 52926 MW; 944B550749C6B94F CRC64;
MTSVTDIPSS GGKSWNQPLT HPGALTDWPQ GQRVNPAQPL RDQSARPRSP GEPWVAPVSS
LPRGGPGQTM AGACDRAPDF LSPSGNQVLW PALGSVVTLN CTASVVSGPH CPLPSVQWLR
DGLLLGNGSH YDLHEDSWVK ANWSEMLVSS VLGINLTSTE DFRTFTCSVQ NISSSSFTLW
RAGLAGHVAA VLASLLVLLV LLLAALLYAK CRLNVLLWYQ DTYGEVEMND GKLYDAYVSY
SDSPEDRKFV NFILKPQLER RRGYKLFLED RDLLPRAEPS ADLLVNLSRC RRLVVVLSDA
FLGRTWCSHS FREGLCRLLE LTRRPIFITF EGQRRDPAHP ALRLLRQHRH LVTLLIWRPG
SVTPSSDFWK ELQLALPRKV QYRAMEGDPQ TRLQDDKDPM LIVGGRVPEG RTLDPELDPD
PEGDLGVRGP VFGEPAAPPH ASGVSLGEGQ GSEVDVSDLG SRNYSARTDF YCLVSEDDV
//
