ID A0A2Y9MIY4_DELLE Unreviewed; 424 AA.
AC A0A2Y9MIY4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=2-oxoglutarate and iron-dependent oxygenase JMJD4 isoform X1 {ECO:0000313|RefSeq:XP_022419002.1};
GN Name=JMJD4 {ECO:0000313|RefSeq:XP_022419002.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022419002.1};
RN [1] {ECO:0000313|RefSeq:XP_022419002.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022419002.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-
CC [protein] + CO2 + succinate; Xref=Rhea:RHEA:57156, Rhea:RHEA-
CC COMP:9752, Rhea:RHEA-COMP:15084, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:141495;
CC Evidence={ECO:0000256|ARBA:ARBA00035905};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022419002.1; XM_022563294.2.
DR AlphaFoldDB; A0A2Y9MIY4; -.
DR STRING; 9749.A0A2Y9MIY4; -.
DR Ensembl; ENSDLET00000018418; ENSDLEP00000016694; ENSDLEG00000012232.
DR KEGG; dle:111169256; -.
DR InParanoid; A0A2Y9MIY4; -.
DR OrthoDB; 120564at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR003347; JmjC_dom.
DR PANTHER; PTHR12480:SF6; 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4; 1.
DR PANTHER; PTHR12480; ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD; 1.
DR Pfam; PF13621; Cupin_8; 1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 143..302
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
SQ SEQUENCE 424 AA; 48810 MW; 0ED132E7D23FAD06 CRC64;
MDREARVFAE SHFRSLEGCL PRRVCPKLDR VDFIEKPDSF SYADFFKGYL LPNLPCVFSS
AFTEGWGSRR LWVTPSGKPN FDYLLQNYGD VVVPVANCGV REYNSNPKEH MTLRDYISYW
KEYIQGNYSS SRGCLYLKDW HLCRDSSAEG VFTLPIYFSS DWLNEYWDAL DVDDYRFIYM
GPTGTWSPFH ADIFRSFSWS VNICGRKKWF FFPPGQEEAL RDCHGSLPYD VTSPTLLDSR
LHPMRDHCSP PLEVTQEAGE MVFVPSGWHH QVHNLEDTIS INHNWVNGCN LANMWHFLQQ
ELCAVQQEII EWRDSMPDWH HHCQVIMKSC SGINFEEFYH FLKVVAERRL LLLAKGMGPG
KVEGGKGTGL GPQQAAFDIC RIAEVLESVV AHPDFQRVDT SAFSPRPEEL LQQLEEAVAA
TTSL
//
