ID A0A2Y9MJ46_DELLE Unreviewed; 1251 AA.
AC A0A2Y9MJ46;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=IQ motif and SEC7 domain-containing protein 2 isoform X2 {ECO:0000313|RefSeq:XP_022422045.1};
GN Name=IQSEC2 {ECO:0000313|RefSeq:XP_022422045.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022422045.1};
RN [1] {ECO:0000313|RefSeq:XP_022422045.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022422045.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR RefSeq; XP_022422045.1; XM_022566337.1.
DR AlphaFoldDB; A0A2Y9MJ46; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 509..702
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..325
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..431
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..956
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1014
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1079
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1143
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1237
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1251 AA; 136304 MW; 4AE3818020D54088 CRC64;
MEPPGRSSSV EGDAPGSDLS TAVDSPGSQP PYRLSQLPPT SSHMGGPPAG VGLPWAQRAR
LQPASVALRK QEEEEIKRSK ALSDSYELST DLQDKKVEML ERKYGGSFLS RRAARTIQTA
FRQYRMNKNF ERLRSSASES RMSRRIILSN MRMQFSFEEY EKAQNPAYFE GKPASLDEGA
MAGARSHRLE RGLPYGGSCG GGIDGGGSSV TTSGEFSNDI TELEDSFSKQ VKSLAESIDE
ALNCHPSGPM SEEPGSAQLE KRESKEQQED SSATSFSDLP LYLDDPVPPP SPERLPSTEP
PPQGRPEFWA PAPLPPVPPP VPPGTREDGS REEGARRGPG CLECRDFRLR AAHLPLLTIE
PPSDSSVDLS DRSDRGSVHR QLVYEADGCS PHGTLKHKGP PGRAPIPHRH YPAPEGPAPA
PPGPLPPAPN SGAGPSGVAG GRRLGKCEAA GENSDGGDNE SLESSSNSNE TINCSSGSSS
RDSLREPPAT GLCKQTYQRE TRHSWDSPAF NNDVVQRRHY RIGLNLFNKK PEKGIQYLIE
RGFLSDTPVG VAHFILERKG LSRQMIGEFL GNRQKQFNRD VLDCVVDEMD FSSMDLDDAL
RKFQSHIRVQ GEAQKVERLI EAFSQRYCVC NPALVRQFRN PDTIFILAFA IILLNTDMYS
PSVKAERKMK LDDFIKNLRG VDNGEDIPRD LLVGIYQRIQ GRELRTNDDH VSQVQAVERM
IVGKKPVLSL PHRRLVCCCQ LYEVPDPNRP QRLGLHQREV FLFNDLLVVT KIFQKKKILV
TYSFRQSFPL VEMHMQLFQN SYYQFGIKLL SAVPGGERKV LIIFNAPSLQ DRLRFTSDLR
ESIAEVQEME KYRVESELEK QKGMMRPNAS QPGGAKDSVN GTLARSSLED TYGAGDGLKR
GALSSSLRDL SDAGKRGRRN SVGSLDSTIE GSVISSPRPH QRMPPPPPPP PPEEYKSQRP
VSNSSSFLGS LFGSKRGKGP FQMPPPPTGQ ASASSSSASS THHHHHHHHH GHSHGGLGVL
PDGQSKLQAL HAQYCQGPGP APPPYLPPQQ PPLPPPPQQP PPLPQLGSIP PPPASAPPVG
PHRHFHAHGP VPGPQHYTLG RPGRAPRRGA GGHPQFAPHG RHPLHQPTSP LPLYSPAPQH
PPAHKQGPKH FIFSHHPQMM PAAGAAGGPG SRPPGGSYSH PHHPQSPLSP HSPIPPHPSY
PPLPPPSPHT PHSPLPPTSP HGPLHASGPP GTANPPTANP KAKPSRISTV V
//
