ID A0A2Y9MLR1_DELLE Unreviewed; 628 AA.
AC A0A2Y9MLR1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Netrin-4 isoform X1 {ECO:0000313|RefSeq:XP_022418093.1};
GN Name=NTN4 {ECO:0000313|RefSeq:XP_022418093.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022418093.1};
RN [1] {ECO:0000313|RefSeq:XP_022418093.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022418093.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_022418093.1; XM_022562385.2.
DR AlphaFoldDB; A0A2Y9MLR1; -.
DR STRING; 9749.A0A2Y9MLR1; -.
DR KEGG; dle:111168717; -.
DR InParanoid; A0A2Y9MLR1; -.
DR OrthoDB; 2916807at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03578; NTR_netrin-4_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR035811; Netrin-4_NTR.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF406; LAMININ SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..628
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016128023"
FT DOMAIN 30..261
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 332..394
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 395..448
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 506..627
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 362..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 422..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 628 AA; 69916 MW; 2EC1A1C4075D4069 CRC64;
MGSCARLLLL WGCSAVAAGL SGVAGLSSRC EKACNPRMGN LALGRKLWAD TTCGQNATEL
YCFYSENTDL TCQQPKCDKC SAAQPHLAHL PAAMADSSFR FPRTWWQSAE DVHREKIQLD
LEAEFYFTHL IMVFKSPRPA AMVLDRSQDF GKTWKPYKYF ATNCPATFGL EDDVVKKGAI
CTSRYSNPFP CTGGEVIFRA LSPPYDVENP YSAKVQEQLK ITNLRVQLLK RQSCPCHRNN
LNAKPQHFTH YAIYDFIVKG SCFCNGHADQ CIPVDGFRPV KAPGAFHVVH GKCMCKHNTA
GTHCQHCAPL YNDRPWEAAD GKTGSPKECR TCKCNGHADA CHFDINVWEA SGNRSGGVCN
DCQHNTEGQH CQRCKPGFYR DLRRPFSAPD ACKLCSCHPV GSAVLPFSSV TFCDPSNGDC
PCKPGVAGPH CDRCMVGYWG FGAYGCRPCD CAGSCDPLTG DCISSSTDID WHHEIPNFHS
MHNKSEPTWE WEDEQGFSAL RHSGKCECKE QVLRNSKAFC GMKYSYVLKI KILSAHDKGS
HAEVNVKIKK VLKSTKLKIL RGKRTLYPES WTNRGCTCPI LNPGLEYLVA GHEDVRTGKL
VVNMKSFVQH WKPSLGRKVM DILKRECK
//
