ID A0A2Y9MMP4_DELLE Unreviewed; 1100 AA.
AC A0A2Y9MMP4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Transmembrane protease serine 9 {ECO:0000313|RefSeq:XP_022422246.1};
GN Name=TMPRSS9 {ECO:0000313|RefSeq:XP_022422246.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022422246.1};
RN [1] {ECO:0000313|RefSeq:XP_022422246.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022422246.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR RefSeq; XP_022422246.1; XM_022566538.2.
DR AlphaFoldDB; A0A2Y9MMP4; -.
DR STRING; 9749.A0A2Y9MMP4; -.
DR KEGG; dle:111170920; -.
DR InParanoid; A0A2Y9MMP4; -.
DR OrthoDB; 4629979at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd00190; Tryp_SPc; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF13; TRANSMEMBRANE SERINE PROTEASE 12; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00089; Trypsin; 3.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00020; Tryp_SPc; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 3.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 3.
DR PROSITE; PS00134; TRYPSIN_HIS; 3.
DR PROSITE; PS00135; TRYPSIN_SER; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000313|RefSeq:XP_022422246.1};
KW Protease {ECO:0000256|RuleBase:RU363034,
KW ECO:0000313|RefSeq:XP_022422246.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000313|RefSeq:XP_022422246.1}.
FT DOMAIN 53..171
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 237..470
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 538..770
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 868..1099
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 773..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 188..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 208..223
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1100 AA; 117876 MW; 2FBCB8D333BB4043 CRC64;
MEPTAGDLQL VPRATKDIQP TDAACCRAAL SAMVATSIVM VTLGVLVASL STQGVNVEHT
AELRGIRFAP SLQQETSDYY RTLTPTLETL FVSSFRETEL EASCVGCTVL SYWEGNASIL
VRFRLHFMQP ALWTPSLGLE EELLQRGLRE RLQGRGIPLA PYGTIVSAQL TGSQKELLTE
RDLKSGHCPG NAFSCGNSQC VTKVNPECDD TADCSDGSDE AHCDCGLQPG WRTAGRIVGG
VEASPGEFPW QVSLRENNEH FCGAAVIGAR WLVSAAHCFN EFQDPTEWVA YAGSTYLSGS
EASTVRARVA RIITHPFYNS DTADFDVAVL ELGGPLPFSR HVQPVCLPAA VHVFPPRKKC
LISGWGYLKE DFLVKPEMLQ KATVELLDQA LCASLYGHSL TDRMLCAGYL DGKVDSCQGD
SGGPLVCEEP SGRFFLAGIV SWGIGCAEAR RPGVYARVTR LRDWILEAIA AASKPLAPTA
APAPAIPSTA WPTSPQSPVV NTPTRPTLAP SAVPLDSATA SKPQECGARP ALEKPTRIVG
GFGAASGEVP WQVSLKEGSR HFCGATVVGD RWLLSAAHCF NHTKVELVRA HLGTASLSGV
GGSPVKMGLR RAVLHPQYNP SILDFDVAVL ELARPLVFNK YVQPVCLPLA IQKFPVGRKC
VISGWGNTQE GNATKPDLLQ RASVGIIDQK ACSALYNFSL TDRMICAGFL EGKVDSCQGD
SGGPLACEET PGVFYLAGIV SWGIGCAQAK KPGVYTRITR LKGWILAIMS SHSLSTPPPS
TTRTPTSSHP ARTTAGLTVL GVVASRPTPW ATSRVTSQPA NRTTTAMTTT TRGQTPPPHA
TETTVGSQLP GAATQDCGLA PAAALTRIVG GSAAGRGEWP WQVSLWLRRR EHRCGAVLVA
ERWLLSAAHC FDVYGDPKQW AAFLGTPFLS GAEGQLERVA RIHKHPFYNL YTLDYDVALL
ELAGPVRRSR LVRPICLPEP APRPPDGARC VITGWGSVRE GGSMARQLQK AAVRLLSEQT
CRRFYPVQIS SRMLCAGFPQ GGVDSCSGDA GGPLACREPS GRWVLTGVTS WGYGCGRPQF
PGVYTRVAAV RGWIGQNIQE
//
