ID A0A2Y9MN93_DELLE Unreviewed; 1008 AA.
AC A0A2Y9MN93;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X10 {ECO:0000313|RefSeq:XP_022423754.1};
GN Name=AGAP1 {ECO:0000313|RefSeq:XP_022423754.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022423754.1};
RN [1] {ECO:0000313|RefSeq:XP_022423754.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022423754.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR RefSeq; XP_022423754.1; XM_022568046.2.
DR AlphaFoldDB; A0A2Y9MN93; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd04103; Centaurin_gamma; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF1; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 619..886
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 907..988
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 1..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 108998 MW; 462E93DAFE04DDD9 CRC64;
MYLLDDSGEP ASPPADAMPR GTPPKKTVYR ISVTMVRKEH LGAPGPGGPD PRPARRPRPA
RSPDAPGRLV EEAEEVACAE DPEGCRPRAW DFRTFRTRST GQLELGRLRP CARGPEPAAL
AGSPPAVEEG TGSPAPGSPD VEGARAAPLR RSLSFRHWSG TEAPRGRALG RGRRHSSSGS
LPWAPGGEAV ADPGAALEPA ASGQPASEKR NTLDVGEVLS KNDGLSDLER WERSKSKNRT
LDNSDLQRLE RARAAAAGSG AALEHRLLRF FSGIFARRDG ATGGGPSPRS GASRPRGYFS
SLRRAPADAH SSSAESIDGS PRRDAFVNSQ EWTLSRSVPE LKVGIVGNLA SGKSALVHRY
LTGTYVQEES PEDMDAGGRF KKEIVVDGQS YLLLIRDEGG PPEAQFAMWV DAVIFVFSLE
DEISFQTVYH YYSRMANYRN TSEIPLVLVG TQDAISSTNP RVIDDARARK LSSDLKRCTY
YETCATYGLN VERVFQDVAQ KIVATRKKQQ LSIGPCKSLP NSPSHSSVCS AQVSAVHISQ
TSNGGGSLSD YSSSVPSTPS TSQKELRIDV PPAANTPTPV RKQSKRRSNL FTSRKGSDPD
KEKKGLESRA DSIGSGRAIP IKQGMLLKRS GKSLNKEWKK KYVTLCDNGV LTYHPSLHDY
MQNVHGKEID LLRTTVKVPG KRPPRATSAC APISSPKTNG LSKDMSSLHI SPNSGNVTSA
PGSQMASGVS LGSFNSRPDG MQQRSYSVSS ADQWSEATVI ANSAISSDTG LGDSVCSSPS
ISSTASPKLD PPPSPHANRK KHRRKKSTSN FKADGLSGTA DAKRKAWKLN RVGSLRNIHN
SSTNTEEQEE NFEFIIVSLT GQTWHFEATT YEERDAWVQA IESQILASLQ SCESSKNKSR
LTSQSEAMAL QSIRNIRGNS HCVDCETQNP NWASLNLGAL MCIECSGIHR NLGTHLSRVR
SLDLDDWPIE LIKVMSSIGN ELANSIWEES TQGRTKPSLD STSFLGGY
//
