ID A0A2Y9MPV6_DELLE Unreviewed; 576 AA.
AC A0A2Y9MPV6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN Name=GLS {ECO:0000313|RefSeq:XP_022422981.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022422981.1};
RN [1] {ECO:0000313|RefSeq:XP_022422981.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022422981.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR RefSeq; XP_022422981.1; XM_022567273.1.
DR AlphaFoldDB; A0A2Y9MPV6; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR HAMAP; MF_00313; Glutaminase; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF49; GLUTAMINASE KIDNEY ISOFORM, MITOCHONDRIAL; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 157..239
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
FT REGION 80..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..120
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 63071 MW; 6A098A757450AFE7 CRC64;
MMRLRGSAML RDLLLRPPAD ACAVLRRAQP LATLCRRPRG GGRAGQAAAA RLYPWWGGGA
RPAGPLVRGL SSSPSEILQE LGKGGTQQPK QQQQQPQQQP PPPPQQPQPG ASPPAAPPAS
GPKDSSGETD GFGNSEGKEL VASGENKIKQ GLLPSLEDLL FYTIAEGQEK IPVHKFITAL
KSTGLRTSDP RLKECMDMLR LTLQTTSDGV MLDKDLFKKC VQSNIVLLTQ AFRRKFVIPD
FMSFTSHIDE LYESAKKQSG GKVADYIPQL AKFSPDLWGV SVCTVDGQRH SIGDTKVPFC
LQSCVKPLKY AIAVNDLGTE YVHRYVGKEP SGLRFNKLFL NEDDKPHNPM VNAGAIVVTS
LIKQGVNNAE KFDYVMQFLN KMAGNEYVGF SNATFQSERE SGDRNFAIGY YLKEKKCFPE
GTDMVGILDF YFQLCSIEVT CESASVMAAT LANGGFCPIT GERVLSPEAV RNTLSLMHSC
GMYDFSGQFA FHVGLPAKSG VAGGILLVVP NVMGMMCWSP PLDKMGNSVK GIHFCHDLVS
LCNFHNYDNL RHFAKKLDPR REGGDQRLGP FFTQVH
//
