ID A0A2Y9MQC1_DELLE Unreviewed; 666 AA.
AC A0A2Y9MQC1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Xaa-Pro aminopeptidase 1 isoform X1 {ECO:0000313|RefSeq:XP_022424519.1};
GN Name=XPNPEP1 {ECO:0000313|RefSeq:XP_022424519.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022424519.1};
RN [1] {ECO:0000313|RefSeq:XP_022424519.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022424519.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR RefSeq; XP_022424519.1; XM_022568811.1.
DR AlphaFoldDB; A0A2Y9MQC1; -.
DR STRING; 9749.A0A2Y9MQC1; -.
DR KEGG; dle:111172322; -.
DR InParanoid; A0A2Y9MQC1; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|RefSeq:XP_022424519.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590};
KW Protease {ECO:0000313|RefSeq:XP_022424519.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 55..191
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 371..585
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 600..662
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 666 AA; 74576 MW; ED77FFB79013065A CRC64;
MAASRKAPRV RANYQDFQLK NLRIIEPNEA TRSGDPGVET DSRMAPKVTS ELLRQLRQAM
RNLEYVTEPI QAYIIPSGDA HQSEYIAPCD CRRAFVSGFD GSAGTAIVTE EHAAMWTDGR
YFLQAAKQMD SNWTLMKMGL KDTPTQEDWL VSVLPEGSRV GVDPLIIPTD YWKKMAKVLR
SAGHHLIPVK ENLVDKIWTD RPERPCKPLI TLGLDYTGIS WKDKVVDLRL KMAERNVVWF
VVTALDEIAW LFNLRGSDVE HNPVFFSYAI IGLETIMLFI DGDRTDAPSV KEHLLLDLGL
EAEYRIQVLP YKSILSELKT LCASLSPREK VWVSDKASYA VSEAIPKDHR CCMPYTPICI
AKAVKNSAES EGMRRAHIKD AVALCELFNW LEKEVPKGGV TEISAADKAE EFRRQQADFV
DLSFPTISST GPNGAIIHYA PVPETNRTLS LDEVYLIDSG AQYKDGTTDV TRTMHFGTPT
AYEKECFTCV LKGHIAVSAA VFPTGTKGHL LDSFARSALW DSGLDYLHGT GHGVGSFLNV
HEGPCGISYK TFSDEPLEAG MIVTDEPGYY EDGAFGIRIE NVVLVVPVKT KYNFSNRGSL
TFDPLTLVPI QTKMIDVDSL TDKECDWLNN YHLTCRDVIG KELQKQGRQE ALEWLIRETQ
PISKQH
//
