ID A0A2Y9MRQ3_DELLE Unreviewed; 1829 AA.
AC A0A2Y9MRQ3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6 {ECO:0000313|RefSeq:XP_022424655.1};
GN Name=GBF1 {ECO:0000313|RefSeq:XP_022424655.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022424655.1};
RN [1] {ECO:0000313|RefSeq:XP_022424655.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022424655.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
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DR RefSeq; XP_022424655.1; XM_022568947.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF388; GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 660..850
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 216..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1400..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1745..1763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1764..1778
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1829 AA; 202708 MW; 95BD7B215F7A285F CRC64;
MVDKNIYIIQ GEISIVVGAI KRNARWSTHT PLDEERDPLL HSFSHLKEVL NNVTELSEIE
PNVFLRPFLE VIRSEDTTGP ITGLALTSVN KFLSYALIDP THEGTAEGME NTADAVTHAR
FVGTDPASDE VVLMKILQVL RTLLLTPVGA HLTNESVCEI MQSCFRICFE MRLSELLRKS
AEHTLVDMVQ LLFTRLPQFK EEPKNYMGTN MKKLKMRAGG MSDSSKWKKQ KRSPRPPRHM
TKVTPGSELP TPSGTTLSSN LTGGMPFIDV PTPISSASSE AASAVVSPST DSGLEFSSQT
TSKEDLTDLE QPGSPGYSTV AEPGSSELGV PEQPDPQQEG AHVEKAQSTS VESIPEVLEE
CTSPADHSDS ASVHDMDYVN PRGVRFTQSS QKEGTALVPY GLPCIRELFR FLISLTNPHD
RHNSEVMIHM GLHLLTVALE SAPVAQCQTL LGLIKDEMCR HLFQMYIKKL MDIITVENPK
MPYEMKEMAL EATVQLWHIP SFVTELYINY DCDYYCSNLF EDLTKLLSKN SFPVSGQLYT
THLLSLDALL TVIDSTEAHC QAKVLNNLTQ QEKKEAARPG CEAVDGTREA NNTERAASDG
KAIGMAPDIA GLHVPGGGRL PAEHGKPGCS DLEEAGDSGA DKKFTRKPPR FSCLLPDPRE
LIEIKNKKKL LITGTEQFNQ KPKKGIQFLQ EKGLLTIPMD NTEVAQWLRE NPRLDKKMIG
EFVSDRKNID LLESFVSTFS FQGLRLDEAL RLYLEAFRLP GEAPVIQRLL EAFTEHWRNC
NGSPFANSDA CFALAYAVIM LNTDQHNHNV RKQNAPMTLE EFRKNLKGVN GGKDFEQDIL
EDMYHAIKNE EIVMPEEQTG LVRENYVWNV LLHRGATPEG IFLRVPAGSY DLDLFTMTWG
PTIAALSYVF DKSLEETIIQ KAISGFRKCA MISAHYGLSD VFDNLIISLC KFTALSSESI
ENLPTVFGSN PKAHIAAKTV FHLAHRHGDI LREGWKNIME AMLQLFRAQL LPKAMVEVED
FVDPNGKISL QREETPSNRG ESTVLSFVSW LTLSGTEQSS VRGPSTENQE AKRMALDCIK
QCDPEKMITE SKFLQLESLQ ELMKALVSVT PDEETYDEED AAFCLEMLLR IVLENRDRVG
CVWQTVRDHL YHLCVQAQDF CFLVERAVVG LLRLAIRLLR REEISGQVLL SLRILLLMKP
SVLSRVSHQV AYGLHELLKT NAANIHSSDD WATLFTLLEC IGSGVKPPAA LQATARADAP
DAGAQSDSEL PSFHQNDVSL DRGYTSDSEV YTDHGRPGKI HRSATDADVV NSGWLVVGKD
DIDNSKPGPE TSWPGPSPLV NQYSLTVGLD LGPHDTKSLL KCVESLSFIV RDAAHITPDN
FELCVKTLRI FVEASLNGGC KSQEKRGKSH KYDSKGNRFK KKSKEGSMLR RPRTSSQHAT
RGGHSDDDED EGVPASYHTV SLQVSQDLLD LMHTLHTRAA SIYSSWAEEQ RHLDTGGRKI
EADSRTLWAH CWCPLLQGIA CLCCDARRQV RMQALTYLQR ALLVHDLQKL DALEWESCFN
KVLFPLLTKL LENISPADVG GMEETRMRAS TLLSKVFLQH LSPLLSLSTF AALWLTILDF
MDKYMHAGSS DLLSEAIPES LKNMLLVMDT AEIFHSADAR GGSPSALWEI TWERIDCFLP
HLRDELFKQT VIQDPVPMEP HAPKPLASAH LTPAAGDTRT PGHPPPPEMP SELGTCDFEK
PEGPRPANSS SSGSPVASSP SRLSPTPDGP PPLAQPPLIL QPLASPLQVG VPPMTLPIIL
NPALIEATSP VPLLATPRPT DPLPTSEVN
//
