ID A0A2Y9MSI6_DELLE Unreviewed; 226 AA.
AC A0A2Y9MSI6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Homeobox protein prophet of Pit-1 {ECO:0000256|ARBA:ARBA00019432};
DE AltName: Full=Pituitary-specific homeodomain factor {ECO:0000256|ARBA:ARBA00030888};
GN Name=PROP1 {ECO:0000313|RefSeq:XP_022420128.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022420128.1};
RN [1] {ECO:0000313|RefSeq:XP_022420128.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022420128.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Possibly involved in the ontogenesis of pituitary
CC gonadotropes, as well as somatotropes, lactotropes and caudomedial
CC thyrotropes. {ECO:0000256|ARBA:ARBA00002030}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_022420128.1; XM_022564420.2.
DR AlphaFoldDB; A0A2Y9MSI6; -.
DR STRING; 9749.A0A2Y9MSI6; -.
DR Ensembl; ENSDLET00000015569; ENSDLEP00000014103; ENSDLEG00000010369.
DR KEGG; dle:111169863; -.
DR InParanoid; A0A2Y9MSI6; -.
DR OrthoDB; 3673628at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0021983; P:pituitary gland development; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR042412; PROP1.
DR PANTHER; PTHR47409; HOMEOBOX PROTEIN PROPHET OF PIT-1; 1.
DR PANTHER; PTHR47409:SF1; HOMEOBOX PROTEIN PROPHET OF PIT-1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 67..127
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 69..128
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 45..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 25314 MW; 8D378FB27508A0A9 CRC64;
MDAEGKSEQG KQKKGRVCSS LWPEDYAAAG TLTSMVDMST QPYRNLSGVR VGRPSLCSQG
EQRGRPHSRR RHRTTFSPAH LEQLESAFGR DQYPDIWARE GLARDTGLSE ARIQVWFQNR
RAKQRKQERS LLQPLAHLSP ATFSGFVPER PACPYSYPTP PPSMTCFPHP YNHALPSQPS
SGGSFARPHQ SEDWYPTLHP TPAGHLPCPP PPPMLPLSLE PPKSWN
//
