ID A0A2Y9MVF2_DELLE Unreviewed; 403 AA.
AC A0A2Y9MVF2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=TBCC domain-containing protein 1 {ECO:0000256|ARBA:ARBA00017559};
GN Name=LOC111172900 {ECO:0000313|RefSeq:XP_022425865.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022425865.1};
RN [1] {ECO:0000313|RefSeq:XP_022425865.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022425865.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens. {ECO:0000256|ARBA:ARBA00003689}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC cytoskeleton, spindle pole {ECO:0000256|ARBA:ARBA00004647}.
CC -!- SIMILARITY: Belongs to the TBCC family.
CC {ECO:0000256|ARBA:ARBA00008848}.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC {ECO:0000256|ARBA:ARBA00009646}.
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DR RefSeq; XP_022425865.1; XM_022570157.1.
DR AlphaFoldDB; A0A2Y9MVF2; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR Gene3D; 2.160.20.70; -; 1.
DR Gene3D; 2.60.20.10; Crystallins; 2.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR017901; C-CAP_CF_C-like.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR036223; CAP_C_sf.
DR InterPro; IPR006599; CARP_motif.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR039589; TBCC1.
DR InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR PANTHER; PTHR16052:SF0; TBCC DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR16052; UNCHARACTERIZED; 1.
DR Pfam; PF00030; Crystall; 2.
DR Pfam; PF07986; TBCC; 1.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00673; CARP; 2.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF69340; C-terminal domain of adenylylcyclase associated protein; 1.
DR SUPFAM; SSF49695; gamma-Crystallin-like; 1.
DR PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Eye lens protein {ECO:0000256|ARBA:ARBA00022613};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..130
FT /note="C-CAP/cofactor C-like"
FT /evidence="ECO:0000259|PROSITE:PS51329"
FT DOMAIN 231..269
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 270..312
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 319..359
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 360..402
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
SQ SEQUENCE 403 AA; 46317 MW; 77243A98F4854074 CRC64;
MHRLVVMSQV YKQTLAKSSD TLVGAHVKIH RCNETFVYLL SPLRSVTIEK CRNSTFILGP
VQTALHLHSC DNVKVIAVCH RLSISSTTGC IFHILTPTRP LILSGNQRVT FAPFHTHYPM
LEDHMARTGL ATVPNYWDNP MIVCRDNSST SVFRLLAPCE FYVFIIPFEM EGDTTEIPGG
LPSAYQKALG QREKKIQTWQ KTVKEARLTN YSWISALGKP IYAPKMSKAG TKITFFEDKN
FQGRHYDSDC DCADFHMYLS RCNSIRVEGG TWAVYERPNF AGYMYILPRG DYSEYQHWMG
LNDRLSSCRA VHLSSGGQYK IQIFEKGDFN GQMYETTEDC PSIMEQFHMR EVHSCKVLEG
AWIFYELPNY RGRQYLLDKK EYRKPVDWGA ASPAVQSFRR IVE
//
