ID A0A2Y9MVY1_DELLE Unreviewed; 1166 AA.
AC A0A2Y9MVY1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Partitioning defective 3 homolog B isoform X2 {ECO:0000313|RefSeq:XP_022423197.1};
GN Name=PARD3B {ECO:0000313|RefSeq:XP_022423197.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022423197.1};
RN [1] {ECO:0000313|RefSeq:XP_022423197.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022423197.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR RefSeq; XP_022423197.1; XM_022567489.2.
DR AlphaFoldDB; A0A2Y9MVY1; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF4; PARTITIONING DEFECTIVE 3 HOMOLOG B; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 164..252
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 346..419
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 461..536
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 47..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..690
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..813
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1129
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1166 AA; 128022 MW; 446D68C35EF5D638 CRC64;
MSDHDPGYWV KIHHLEYTDG GILDPDDVLA DVVEDKDKLI AVFDEQEPLH KIESPSGNPA
GRQSPDAFET EVAAQLAAFK PVGGEIEVTP SALKLGTPLL VRRSSDPAPS PPADAKPSAS
HPSGQSLKPV IPNSTQDLED EVMNGVQTEL LTSPKTMDAL SNMTRTVEIS GEGGPLGIHV
VPFFSSLSGR ILGLFIRGIE ENSRSKREGL FHENECIVKI NSVDLVDKTF AQAQDVFRQA
MKSPSVLLHV LPPQNREQYE KSVTGPLNIF GNNDGVLRTK VPPPVHGKSG MKTVNLTGTS
SPEEDASTSL QQSKSPRVPR LGRKPSSPSL SPLMGFGSKK NAKKIKIDLK KGPEGLGFTV
VTRDSSIHGP GPIFVKNILP KGAAIKDGRL QSGDRILEVN GRDVTGRTQE ELVAMLRSTK
QGETASLVIA RQEGTFLPRE LKGEPDCYAL SLETTEQLTF EIPLNDSGSA GLGVSLKGNK
SRETGTDLGI FIKSIIHGGA AFKDGRLQVN DQLIAVNGES LLGKSNHEAM ETLRRSMSME
GNIRGMIQLV ILRRPGRPLE EPAECGAFSK PCFENCQNAV TTSRRNDTST LHSFGTYSPQ
NKQKELLLPN DGWAESGGPP PPPHPVLELG LEDYSHSSGV DAAVFFPDQR LNFRSATPAR
QPESMNLKAS KSMDLVPDES KVHSLAGHKS DSPSKDFGPT LGLKKSSSLE SLQTAVAEVR
KNELPFHRPR PHVVRGRGCN ESFRAAIDKS YDGPEELEAD GLSDKSSHSG QGALNYESAP
QGNSELENAE NKARKVKKPK EKEKKKEKGK FKVKVKKQKE GNEDPERKIK RKGFGAMLRF
GKKKDDKGGK AEQKGPLKHG GLREEELEKM KEERERIGAK HQELREKQAR GLIDYAAGAI
GSLHDMDDDE MDPNYARVNH FREACAPANV YRSPSPPRAG PLGYPRDGRP LSPERDHLEG
LYAKVNKPYH PPVPVDSGRS ISGSTDRIQK LRKEYYQARR EAFALCEDSE GRARPDYDLH
WVSGKGPDGN AHNLRFEGME RQYASLPRGG PVDPVDYLTA APRGLYKERE LPYYPGAHPV
HPPKGSYPRP PDLRITDLRY PQYYPPPPAP QHKGPFRQDV PPSPPQHHRV PAYPEMGRPV
PRGGSPDQYP YRMQDPRQKN PMTAAV
//
