ID A0A2Y9MWW1_DELLE Unreviewed; 2194 AA.
AC A0A2Y9MWW1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dedicator of cytokinesis protein 10 isoform X9 {ECO:0000313|RefSeq:XP_022423527.1};
GN Name=DOCK10 {ECO:0000313|RefSeq:XP_022423527.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022423527.1};
RN [1] {ECO:0000313|RefSeq:XP_022423527.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022423527.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_022423527.1; XM_022567819.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11699; DHR2_DOCK10; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 175..284
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 666..844
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1688..2148
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 147..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2173..2194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2194 AA; 251488 MW; AB7CD40D1C2F1224 CRC64;
MSFRGKVFKR DPSEFWKKRR TMRRKNQEEI HRFSSQEKPR LLQPLDYETV IEELEKTYQN
DPLRDLLFFP SDDFSTATVP WDIRTLYSTV PEDAEHKAEN LLVREACKFY SSQWYVVNYK
YEQYSGDIRQ LPRAEYKPEK LPSHSFEVDH EDADKDEDTT SHSSSKGGGG MGGTGVFKSG
WLYKGNFNST VNNTITVRSF KKRFFQLTQL PDNSYIMNFY KDEKISKEPK GCIFLDSCTG
VVQNNRLRKY AFELKMNDLT YFVLAAETES DMDEWIHTLS RILQISPEGP PQGRRSAELT
ELGLDSLDNS ITCECTPEET DSSENNLHPD FTKYLTETEE IVKATRNTER LNLFLLDPDI
DSLKLQKKDL LEPEFVIKPF EEKAAKRIMI ICKALNLNLQ GCVTENENDP VTNIEPFFVS
VALYDLRNSR KISADFHVDL NHTAVRQMLS GASVALENGN IDTVTPRQSE EPHVKGFPEE
WLKFPKQAIF SVSNPHSEIV LVAKIEKVLM GNIASGAEPY IKNPDSNKYA QKILKSNRQF
CSKLGKYRMP FAWAVRSVFK DNQGNVDRDS RFSPLYRQES NKISTEDLLK LVSDYRRADR
ISKTQTIPGS LDIAVDNIPL EHPNCVTSSF IPVKPFNVTA QPEPTVEVEE FVYDSAKYCR
PYRVYKNQIY IYPKHLKYDS QKCFNKARNI TVCIEFKNSD EEDAKPVKCI YGKPGGPLFT
SATYTAVLHH SQSPDFSDEV KIELPTQLHE KHHIFFSFYH VTCDINAKAN AKKKEALETP
VGYAWLPLMR DDQIASQEYN IPVATSLPPN YLSFQDSASG KHGGSDIKWV DGGKPLFKVS
TFVVSTVNTQ DPHVNAFFRQ CQKREKDMSQ SPTSSFVRSC KNLLNVEKIH AIMSFLPVIL
NQLFRVLVQN EEDEISTTVT RVLTDIVTKC HEEQLDHCVQ SYIKFVFKTT ACKERTIHEE
LVKNVTGLLQ SNDSTTVKHV LKHSWFFFAI ILKSMAQHLI DTNKIQLSRP QRFPESYQNE
LDNLVMSLAD HMIWKNKNAL EETRRANHSV ARFLKRCFTF MDRGFVFKTV NSYVSMFSSG
DPKTLCQYKF DFLQEVCQHE HFIPLCLPIR SANIPDPLTP SESIQELHAS DMPEYSVTNE
FCRKHFLIGI LLREVGFALQ EDQDIRHLAL AVLKNLMAKH SFDDRYREPE KQAQIASLYM
PLYGMLLDNM PRIYLKDLYP FTINTSNQGS RDDLSTNGGF HTQSAMKYAN SVDTSFSKDV
LNSIAAFSSI AISTVNHADS RASLASLDSN PSTNEKSSEK TDNCEKIPRP LSLIGSTLRF
DKLDQAETRS LLMCFLHIMK TISEETLIAY WQRAPSPEVS DFFSILDVCL QNFRYLGKRN
IISFPCRKIA AAFKFVQSTQ NNGTLKGSNP SCQTSGLLPQ WMHTTSSHEG QKQHRSQTLP
IIRGKNALSN PKLLQMLDNT MTSNSNEIDI VHHVDTEANI ATEVCLTILD LLALFTQVHQ
RQLQQSECQN SMMKRVFDTY MLFFQVNQSA TALKHVFASL RLFVCKFPSA FFQGPADLCG
SFCYEVLKCC NHRSRSTQTE ASALLYFFMR KNFEFNKQKS IVRSHLQLIK AVSQLIADAG
IGGSRFQHSL AITNNFANGD KQMKNSNFPA EVKDLTKRIR TVLMATAQMK EHEKDPEMLV
DLQYSLANSY ASTPELRRTW LESMAKIHAR NGDLSEAAMC YIHIAALIAE YLKRRGYWKM
EKICTPSLLP EDIHPRDSNL LLTTPSGGSM FSMGWPAFLS ITPNIKEEGA MKEDSGMQDT
PYNENILVEQ LYLCVEFLWK SERYELIADV NKPIIAVFEK QRDFKKLSDL YYDIHRSYLK
VAEVVNSEKR LFGRYYRVAF YGQGFFEEEE GKEYIYKEPK LTGLSEISQR LLKLYADKFG
ADNVKIIQDS NKVNPKDLDP KYAYIQVTYV TPFFEEKEIE DRKTDFEMHH NINRFVFETP
FTPSGKKHGG VEEQCKRRTV LTTSHLFPYV KKRIQVISQS STELNPIEVA IDEMSKKVSE
LNQLCTMEEV DMIRLQLKLQ GSVSVKVNAG PMAYARAFLE ETNAKKYPDN QVKLLKAIFR
QFADVCGQAL DVNERLIKED QLEYQEELRS HYKDMLSELS AIMSEQITYQ DGPSKRGVEQ
TCTRVINKAA PSLSHPVQKF EGESATSDTP PREL
//
