ID A0A2Y9MXA7_DELLE Unreviewed; 2150 AA.
AC A0A2Y9MXA7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Bromodomain adjacent to zinc finger domain protein 2B isoform X7 {ECO:0000313|RefSeq:XP_022425531.1};
GN Name=BAZ2B {ECO:0000313|RefSeq:XP_022425531.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022425531.1};
RN [1] {ECO:0000313|RefSeq:XP_022425531.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022425531.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022425531.1; XM_022569823.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 676..747
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1033..1098
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1914..1964
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2059..2129
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..225
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..597
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1266
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1431..1484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1536..1550
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1607..1639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2150 AA; 238737 MW; E758DF8A206EEEDA CRC64;
MESGERLPSS AASSATPTSS SIPSVASSVS KGGLSTGAAS LSSTINPCGA EWWRTTDAHT
RAGATFFPPL LGIPPLFAPP AQNHDSSSFH SRASGKSNRN GPEKGVNGSI NGNNTSSVSG
INTSVLSTTA SSSVGQTKSI SSGGGNRKCS QEPNKTQPLD ARADKIKDKK PRKKAMESSS
NSDSDSGTSS DTSSEGISSS DSDDLEEDEE EEDQSIEESE DDDSDSESEA QHKSNNQVLL
HGVSDPKAEG QKATEKAQEK RIHQPLPLVS ESQTHSSFQS QQKQPQVLSQ QLPFIFQSSQ
AKEESVNKHT SVIQSTGLVS NVKPLSLVNQ AKKEIYMKLI VPSPDVLKAG NKNTSEESSP
LTSELRSKRE QYKQTFPAQL KKQESSKSLK KVIAALSNPK ATSSSPAHPK QTLENNHPNP
FLTNALLGNH QPNGVIQSVI QEAPLALTTK TKMQSKINEN IATSSSTPFS SPVNLSTSGR
RTPGNQTTVM PSASPILHSQ GKEKAVSNNV NTVKTQHHSH PAKSLGEQFR GADSDIPSSK
DSEDSNEEEE EDDEEEDEED EDDESDDSQS ESDSNSESDT EGSEEDDDGD KDQDESDSDT
EGEKTSMKLN KTASSVKSPS ISLTAHSTPR NLHIAKAPGS APAALCSESQ SPAFLGTPSS
TLTSSPHSGT SKRRRVTDER ELRIPLEYGW QRETRIRNFG GRLQGEVAYY APCGKKLRQY
PEVIKYLSRN GIMDISRDNF SFSAKIRLGD FYEARDGPQG MQWCLLKEED VIPRIRAMEC
RRGRPPNPDR QRAREESRMR CRKGRPPNVG SAEFLDNTDA KLLRKLQAQE IARQAAQIKL
LRKLQKQEQA RVAKEAKKQR AIMAAEEKRK QKEQIKIMKQ QEKIKRIQQI RMEKELRAQQ
ILEAKKKKKE EAANAKLLEA EKRIKEKEMR RQQAVLLKHQ ELERHRLDME RERRRQHMML
MKAMEARKKA EEKERLKQEK RDEKRLNKER KLEQRRLELE MAKELKKPNE DMCLADQKPL
PELPRIPGLV LSGSTFSDCL MVVQFLRNFG KVLGFDVNID VPNLSVLQEG LLNIGDSMGE
VQDLLVRLLS AAVCDPGLIT GYKAKTALGE HLMNVGVNRD NVSEILQIFM EAHCGQTELT
ESLKTKAFQA HTPAQKASVL AFLINELACS KSVVSEIDKN IDYMSNLRRD KWVVEGKLRK
LRIIHAKKTG KRDPSGGIDL GEEQHPLGTP TPGRKRRRKG GDSDDDDDDD EDSDDQADED
DEDEEDKEDK KGKKAEICED EDEGDQAASV EELEKQIEKL SKQQSQYRRK LFDASHSLRS
MMFGQDRYRR RYWILPQCGG IFVEGMESGE GLEEIAKERE KLKKAESIQI KEEIFETSED
TLNCSNPNHC EQKEDTKEKD NTNLFLQKPG SFSKLSKLLE VAKMPPESDV ITPKPNSSAN
GCTLSYQNSG KHSLGSIQST ATQSSVEKTD SNNLFNTSSG GPGKFYSPLP NDQLLKTLTE
KNRQWFSLLP RTPCDDTSLT HAGMSTASLV APQSQPPSKS PSPAPAPLPG SSSAQNPVGL
NPFALSPLQM KSGVSMMGLQ FCGWPTGVLT SSNPFTSPLP SLGSGLGLPE GNSNSFLTPN
VASSKSESPV PQNEKVSSTQ PVAVEVAKPV DFPNPKPIPE EMQFGWWRII DPEDLKALLK
VLHLRGIREK ALQKQIQKHL DYITQACIKN KDVAIIELNE HEENQVTRDI VENWSVEEQA
MEMDLSILQQ VEDLERRVAS ASLQVKGWMC PEPASEREDL VYFEHKSFSK LCKEHDGEFT
GEEESSAHAL ERKSDNPLDI AVTRLADLER NIERRYLKSP LSTTIQIKLD NVGTVTVPAP
APSISGDGDG IEEDIAPGLR VWRRALSEAR SAAQVALCIQ QLQKSVAWEK SIMKVYCQIC
RKGDNEELLL LCDGCDKGCH TYCHRPKITT IPDGDWFCPA CIAKASGQTL KIKKLHVKGK
KTESKKGKKV TLTGDTEDED SASTSSSLKR GIKDLKKRKM EENTSISLSK QESFTSVKKP
KRDDSKDLAL CSMILTEMET HEDAWPFLLP VNLKLVPGYK KVIKKPMDFS TIREKLSSGQ
YPNLETFALD VRLVFDNCET FNEDDSDIGR AGHSMRKYFE KKWTDTFKVS
//
