ID   A0A2Y9N085_DELLE        Unreviewed;      1118 AA.
AC   A0A2Y9N085;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Limbin isoform X3 {ECO:0000313|RefSeq:XP_022422733.1};
GN   Name=EVC2 {ECO:0000313|RefSeq:XP_022422733.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022422733.1};
RN   [1] {ECO:0000313|RefSeq:XP_022422733.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022422733.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
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DR   RefSeq; XP_022422733.1; XM_022567025.1.
DR   AlphaFoldDB; A0A2Y9N085; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR   InterPro; IPR022076; Limbin.
DR   InterPro; IPR026501; Limbin/EVC.
DR   PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR   PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR   Pfam; PF12297; EVC2_like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1118
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016013141"
FT   TRANSMEM        288..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          30..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1042..1062
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          454..481
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          698..725
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1070..1104
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        43..57
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1048..1062
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1118 AA;  126870 MW;  49CE57DD62428BA3 CRC64;
     MGSAGARGRA MWVLAGGLLA AALALPAGSG DRGRLPADPG PLRRPLGAQP PQNPRSAPGV
     GPEQTAEDLP HGIWPSVESS HFLTAVEAPF GMKFNKKTEV FNPPPNSAAS SGPWIHSIFA
     FIPSWPKKTL FKRESAVTHH LYGDISRDIQ GTSENGVIFQ KCAVVSVQSE WPTAHVRLSV
     NNTRAPAAAN LSDLLLLDNI TGLTVRESAG NQTSRGFQAF RKKFLQVGDS FSVSYTASLE
     ARDVGSGEVL MLPAQLSFQS SSPNRAQLKA LFTITTEEKI TVLPNHGLHA AGFFVAFILS
     LVLTWAVLFF MVRYQCLKGS MLTRHQVQHH ESKLERSQFT SADGMNEDLA LNDQMIDILS
     SEDPGSMLQA LEELEIATLN RADSDLEACR TQISKDIIAL LLKNLTSSGH LSPQVERRMG
     AVFKKQFLLL EKEIQDEYDR KMVALTAECD LETRKKTESQ YQREMAAMEE AEEVLKRVSE
     RSAIECSSLL RTLHGLEQEH LRRSLALQQE EDFAKAHRQL AIFQRNELHS IFFTQIKSAI
     FKGELKPEAA KMLLQDYSKI QENVEELMDF FQASKRYHLS KRFGHREYLV QNIQSSETRV
     QGLLSTASAQ LTLLIQKHER AGYLDEDQMR VLLERAQTEV FSIKQKLDND LKQEKKKLHQ
     KLIIKRRREM LQKHKEQRRE RLSIAEAFGA AEDARQYMGQ WRSLVAEHSA TLEELQERLD
     QAALDELRAL TLSLSEKATE QLRRLQNSVM TQELLKRGVP WLFLQQILEE HSRDLAARAE
     RLEGEERDRG QEGIQSVRQR LKDDALEAST EEQAELRHWE HLIFTKLWSS AFSLSEEELL
     GMRQEVHGCF AQMDRSLALP KIRARVLLQQ FQTAWREAEF LKLDQALAAP ELQPQSKARK
     PRSKSKSKTD LLKKCTEDKI QLFEEQAPED LVEKVRGELL RERVQQLEAQ EGRFAESLVS
     LQFQKAARMA KTLWAYTALL TIQDLLLEEL SASETLTKSA CTQILESHSP ELQELERKLE
     DQLARQEAAQ LQRALESRQQ WAGEGPGLLH EPEEETDSER QVSAVLRRAL SKGQKLLERH
     QQSLREEQEN SVMLEDLLEN METDTFVTLY SQVRAVRL
//