ID A0A2Y9N0Q4_DELLE Unreviewed; 819 AA.
AC A0A2Y9N0Q4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=ITGB7 {ECO:0000313|RefSeq:XP_022427770.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022427770.1};
RN [1] {ECO:0000313|RefSeq:XP_022427770.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022427770.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR RefSeq; XP_022427770.1; XM_022572062.2.
DR AlphaFoldDB; A0A2Y9N0Q4; -.
DR STRING; 9749.A0A2Y9N0Q4; -.
DR KEGG; dle:111173950; -.
DR InParanoid; A0A2Y9N0Q4; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF36; INTEGRIN BETA-7; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 747..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..111
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 69..497
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 666..743
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 768..814
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT REGION 111..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 70..80
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 73..110
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 83..99
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 235..242
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 290..330
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 469..709
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 495..499
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 509..521
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 518..558
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 523..532
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 534..548
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 564..569
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 566..595
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 571..580
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 582..587
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 601..606
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 603..634
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 608..617
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 619..626
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 640..645
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 642..687
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 647..656
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 659..662
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 666..675
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 819 AA; 89335 MW; A9A506C06177B0B2 CRC64;
MHECYHLACQ LCVTDYDETM VALSMVLVFL LALSRGESEL DIKISSPQET TEWGDPGLSL
PGSCQPAPSC QKCILSHPSC AWCKQLNFTA SGEAEVRRCA LREELLARGC PPEELEEPRG
RQEVLQDKPL SQGTRGEGAT QLAPQRVRVT LRPGEPQQLR VRFLRAEGYP VDLYYLMDLS
YSMKDDLERV RQLGHALLVR LQEVTHSVRI GFGSFVDKMV LPFVSTVPSK LRHPCPTRLE
RCQPPFSFHH VLPLTRDAKA FEREVGRQSV SGNLDSPEGG FDAILQAALC QEQIGWRNVS
RLLVFTSDDT FHTAGDGKLG GIFMPSDGHC HLDSNGLYSR SPEFDYPSVG QVAQALSAAN
IQPIFAVTGA TLPVYQELSK LIPKSVVGEL SEDSSNVVQL IMDAYNSLSS TVTLEHERSL
LPPGVHISYD SQCGGPEKKQ DEAGDRGQCN HVGINQTVNF LVTLQATHCL PEPHLLRFRA
RGFSEELTVE LHTLCDCNCS DTQLQAPHCS DGKGHLQCGV CSCVPGHLGR LCECSEAELS
SWDLESGCRA PNGTGPLCSG RGRCQCGRCT CSGQSSGRLC ECDDASCERH EGILCGGFGR
CQCGVCHCHA NRTGRACECS GDTDNCVSHD GGLCSGHGYC NCNRCQCSDG YYGALCGQCS
GCKTPCERHR DCAECGALGT GPLAVNCSLA CAHANVTLAL APTLDDGWCK ERTHDNQLFF
FLAEDEAGGR VTLRVRPPQK GSDHTQIIVL GCVGGIVVVG LGLVLAYRLS VEIYDRREYS
RFEKEQQQLQ WKQDNNPLYK SAITTTVNPC FQEAEGAPL
//
