ID A0A2Y9N0X2_DELLE Unreviewed; 744 AA.
AC A0A2Y9N0X2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=PMS1 protein homolog 1 isoform X3 {ECO:0000313|RefSeq:XP_022422953.1};
GN Name=PMS1 {ECO:0000313|RefSeq:XP_022422953.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022422953.1};
RN [1] {ECO:0000313|RefSeq:XP_022422953.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022422953.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022422953.1; XM_022567245.1.
DR AlphaFoldDB; A0A2Y9N0X2; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03485; MutL_Trans_hPMS_1_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 384..452
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 384..452
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 277..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 434..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 285..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 85068 MW; 4D22479EE9C9BE3E CRC64;
MDKEDVAIIW QKTRVSDHKM ALMSVLGTAV MGNMEPFQYH SEESQIYLSG FLPKHDADHS
FTSLSTPERS FIFINSRPVH QKDILKLIRH YYNLKCLKES TRLYPIFFLK IDVPTADVDV
NLTPDKSQVL LQNKESVLIA LENLMTTYYG SLTSTNSYES NKTDVSSDDM VVSKTTETDV
LFTTMETSGN NYPNVDTSAV PFQNDVHNDK SGQNTNYCLN HHMHIGDHCD DHFNSENSSI
DKNSGNTFQE IPMNNLSCED TQKEHSEVCF VGSVKQAQSE NGSKGHIDES GENEEEAVPE
KSLEICVDDW SKGNVLKDSR GENIEPVKIL VPQESLACKV SNNNNNPSPE QKNLNESSYN
KKSNVVDNKS GQLTAYDLIS NRVIKKPMSA SALFVQDHRA QFLTDNSKTS LEDAAVQIEE
LWKTLSEEEK LKYEEKATKD LERYNRQIKR AIEQESQVSL KDGKKRIKPT SAWNLAQKNK
LKTSLSNQPK LDELFQSQIE KKTQNIKKVQ IPFSMENLKK NSDKHRKFDL EETDESYLIH
NLKFPDAWLI TSKTEIMLLN PYRVEEALLF KRLLENHKLP AEPLEKPIIL TESLFNGSHY
LEILHKMTAD DQRYSGSTYL SDPRLTANGF KIKLIPGVSI AENYLEIEGM ANCLPFYGVM
DLKEILNAIL NKNAKEVYEC RPRKVISYLE GEAVRLSRQL PMYLSKEDIQ DIIYRMKHQF
GNEIKGCVHG RPFFHHLTHL PEAT
//
