ID A0A2Y9N3L4_DELLE Unreviewed; 692 AA.
AC A0A2Y9N3L4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Calcium-binding and coiled-coil domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040932};
GN Name=CALCOCO1 {ECO:0000313|RefSeq:XP_022427716.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022427716.1};
RN [1] {ECO:0000313|RefSeq:XP_022427716.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022427716.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CALCOCO family.
CC {ECO:0000256|ARBA:ARBA00037963}.
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DR RefSeq; XP_022427716.1; XM_022572008.1.
DR AlphaFoldDB; A0A2Y9N3L4; -.
DR STRING; 9749.A0A2Y9N3L4; -.
DR Ensembl; ENSDLET00000005322; ENSDLEP00000004773; ENSDLEG00000003663.
DR KEGG; dle:111173930; -.
DR InParanoid; A0A2Y9N3L4; -.
DR OrthoDB; 3062393at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0030518; P:intracellular steroid hormone receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21967; Zn-C2H2_CALCOCO1; 1.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 6.20.250.40; -; 1.
DR InterPro; IPR012852; CALCOCO1-like.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR041611; SKICH.
DR PANTHER; PTHR31915:SF5; CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR31915; SKICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07888; CALCOCO1; 1.
DR Pfam; PF17751; SKICH; 1.
DR Pfam; PF18112; Zn-C2H2_12; 1.
DR PROSITE; PS51905; ZF_UBZ1; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 654..680
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT REGION 514..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 146..208
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 251..334
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 419..513
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 692 AA; 77153 MW; 2E6CDC226AEDCBB0 CRC64;
MEESSLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT VPSASDWIGI FKVEAACVRD
YHTFVWSSVP ESATDGSPIH ASVQFQASYL PKPGAQLYQF RYVNRQGRVC GQSPPFQFRE
PRPMDELVTL EETDGGSDIL LVVPKATVLQ NQLDESQQER NDLMQLKLQL EGQVIELRSR
VQELETALAS ARQEHVALEE QYKGLSRSHG ELTEERDILS RQQGDHVARI LELEDDIQTI
SEKVLTKEVE LDRVRDTVKA LTREQEKLLG QLKEMQADKE QSEAELQVAQ QENCRLNLEL
QEARGRQEEQ SAQAQRLKDK MAQMKDTLGQ AQQRVAELEP LKEQLRGAQE LAASSQQKAA
LLGEELASAA GARDRTIAEL HRSRLEVAGV NGRLAELSLH LKEEKSQWSK ERAGLLQSVE
AEKDKILKLS AEILRLEKAV QEEKTQNQVF KTELAQEKDS SLVQLSESRR ELVELRSALR
VLQKEKEQLQ EEKQELLEYM RKLEARLEKV ADEKWNEDPA TEDEEAAAGL RCPVALTDSE
DESPEDMRLP PYGLCERGDL GSSPATGPRE ASPLVVISQP APIAPHLSGP AEDSSSDSEA
EDEKSVLMAA VQSGGEEANL LLPELGNAFY DMASGFAAGP LSEASTGGPT TPPWKECPIC
KERFPAESDK DALEDHVDGH FFFSTQDPFT FE
//
