ID   A0A2Y9N3T9_DELLE        Unreviewed;       235 AA.
AC   A0A2Y9N3T9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE            EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN   Name=USP4 {ECO:0000313|RefSeq:XP_022428875.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022428875.1};
RN   [1] {ECO:0000313|RefSeq:XP_022428875.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022428875.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR   RefSeq; XP_022428875.1; XM_022573167.2.
DR   AlphaFoldDB; A0A2Y9N3T9; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   Gene3D; 3.30.2230.10; DUSP-like; 1.
DR   InterPro; IPR035927; DUSP-like_sf.
DR   InterPro; IPR006615; Pept_C19_DUSP.
DR   InterPro; IPR028135; Ub_USP-typ.
DR   Pfam; PF06337; DUSP; 1.
DR   Pfam; PF14836; Ubiquitin_3; 1.
DR   SMART; SM00695; DUSP; 1.
DR   SUPFAM; SSF143791; DUSP-like; 1.
DR   PROSITE; PS51283; DUSP; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|RefSeq:XP_022428875.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT   DOMAIN          11..122
FT                   /note="DUSP"
FT                   /evidence="ECO:0000259|PROSITE:PS51283"
SQ   SEQUENCE   235 AA;  27111 MW;  39FAF410C788A4AD CRC64;
     MAEGGGCCER PDAETQKSEL GALMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYSVG
     EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPAEA WNKLLNWYGC VEGQQPIVRK
     VVEHGLFVKH CKVEVYLLEL KLCENSDPTN VLSCHFSKSD TIATIEKEMR KLFNIPADRE
     TRLWNKYMSN TYEQLSKLDN TVQDAGLYQG QVLVIEPQNE DGTWPRQTLQ SKPVQ
//