ID   A0A2Y9N4S6_DELLE        Unreviewed;       502 AA.
AC   A0A2Y9N4S6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=THUMP domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_022429704.1};
GN   Name=THUMPD2 {ECO:0000313|RefSeq:XP_022429704.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022429704.1};
RN   [1] {ECO:0000313|RefSeq:XP_022429704.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022429704.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000256|ARBA:ARBA00008361}.
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DR   RefSeq; XP_022429704.1; XM_022573996.2.
DR   AlphaFoldDB; A0A2Y9N4S6; -.
DR   STRING; 9749.A0A2Y9N4S6; -.
DR   Ensembl; ENSDLET00000006828; ENSDLEP00000006155; ENSDLEG00000004611.
DR   KEGG; dle:111174843; -.
DR   InParanoid; A0A2Y9N4S6; -.
DR   OrthoDB; 5406466at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd11715; THUMP_AdoMetMT; 1.
DR   Gene3D; 3.30.2130.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   SMART; SM00981; THUMP; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF143437; THUMP domain-like; 1.
DR   PROSITE; PS51165; THUMP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          141..265
FT                   /note="THUMP"
FT                   /evidence="ECO:0000259|PROSITE:PS51165"
FT   REGION          419..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..437
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   502 AA;  55346 MW;  0F95461D96EB815A CRC64;
     MAAVPGGRRS GPAAGARFFC TAGRGLEPFL MREVRSRLAA TQVEYISGKV FFTTCSDLNM
     LKKLKSAERL FLLIKKQLPF NVSSVSKGKI FNEMQRLTND DPESWLNAIS IWKNLLELNA
     KKVKLSQKNA NPLKRKVGEN DIIAKKLKTA EMQEIQEKKE CQVEKQIEEE TLEQGNFTTK
     RDKSQEELQN DVAEAVDTHN QNDLTFRVSC RCSGAIAKTF TAQEAGRVIG IALMKQFGWK
     ADLRNPNVEI FIHLSDIYCV VGIPVFRVPL ASRAYIKTAG LRSTIAWAMA SLAEIKAGAV
     VLDPMCGLGT ILLEAAKEWP DVYYVGADVS DSQLLGACDN LKAAGLKDKI ELLKVSVIEL
     PLPSESVDTI ISDIPFGKKF KLGKDIKHII QEMERVLRVG GTIVLLLSED HHRRLKGCEE
     SSVPLNSKGS RTDKPGSTEL LNPEEKAAIS QPASSSFAAS NQECLDGMPP FGSLVPVECY
     RVSLGKTDAL IYKYKKSHSP GQ
//