ID A0A2Y9N4U3_DELLE Unreviewed; 821 AA.
AC A0A2Y9N4U3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Amyloid-beta A4 precursor protein-binding family A member 1 isoform X2 {ECO:0000313|RefSeq:XP_022429255.1};
GN Name=APBA1 {ECO:0000313|RefSeq:XP_022429255.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022429255.1};
RN [1] {ECO:0000313|RefSeq:XP_022429255.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022429255.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022429255.1; XM_022573547.1.
DR AlphaFoldDB; A0A2Y9N4U3; -.
DR Ensembl; ENSDLET00000014948; ENSDLEP00000013535; ENSDLEG00000009910.
DR Proteomes; UP000248483; Unplaced.
DR CDD; cd22578; Mint1_CID; 1.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01208; PTB_X11; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR12345:SF14; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1; 1.
DR PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 452..627
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 640..725
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 731..807
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 91010 MW; A624AA8925A6B8F2 CRC64;
MNHLEAAAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ HHAGRPLRGR AVEDLRAQPG
PQQQQEEEER GECLARSAST ESGFHNHTDT AEGDVIAAAR EGYDAERAQD PEDESAYAVQ
YRPEAEEYTE QAEAEHAEAT HRRALPNHLH FHSLEHEEAM NAAYSGYVYT HRLFHRGEDE
PYAEPYADYG GLQEHVYEEI GDAPELDARD GLRLYEQERD EAAAYRQEAL GARLHHYDER
SDGESDSPEK EAEFAPYPRM DSYEQEEDID QIVAEVKQSM SSQSLDKAAE DMPEAEQDLE
RAPTPGGGRP DSPGLQAPAG QQRAAGGEAV QRYSKEKRDA ISLAIKDIKE AIEEVKTRTI
RSPYTPDEPK EPIWVMRQDI SPTRDCDDQR PVDGDSPSPG SSSPLGAESS STPLHPSDPT
EASTNKESRK SLASFPTYVE VPGPCDPEDL IDGIIFAANY LGSTQLLSDK TPSKNVRMMQ
AQEAVSRIKA PEGESQPMTE VDLFISTQRI KVLNADTQET MMDHPLRTIS YIADIGNIVV
LMARRRMPRS NSQENVEASH PSQDGKRQYK MICHVFESED AQLIAQSIGQ AFSVAYQEFL
RANGINPEDL SQKEYSDLLN TQDMYNDDLI HFSKSENCKD VFIEKQKGEI LGVVIVESGW
GSILPTVIIA NMMHGGPAEK SGKLNIGDQI MSINGTSLVG LPLSTCQSII KGLKNQARVK
LNIVRCPPVT TVLIRRPDLR YQLGFSVQNG IICSLMRGGI AERGGVRVGH RIIEINGQSV
VATPHEKIVH ILSNAVGEIH MKTMPAAMYR LLTAQEQPVY I
//
